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3D Ultrasound Validation for Measuring Stomach Volume (3DUSstomach)

This study has been completed.
Sponsor:
Information provided by:
Mayo Clinic
ClinicalTrials.gov Identifier:
NCT00588224
First received: December 22, 2007
Last updated: July 20, 2009
Last verified: July 2009
History of Changes
  Purpose

The goal is to study the accuracy of 3-dimensional ultrasound (which does not involve radiation) to measure the size of the stomach, comparing it with a previously validated method that involves radiation. This will make it possible to check the stomach function of children without exposing them to radiation. A second goal is to measure the size of the stomach and the effect of a standard meal on stomach volume in adolescent boys and girls.


Condition Intervention
Healthy
 Other: 3D ultrasound

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Validation and Application of 3-dimensional Ultrasound for Measurement of Gastric Volumes in Healthy Subjects

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • Fasting and Postprandial gastric volumes measured by 3D ultrasonography in adults and adolescents [ Time Frame: one month ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Intra and inter-individual COV in adults for fasting and postprandial volumes [ Time Frame: one month ] [ Designated as safety issue: No ]
  • Accuracy of 3D-ultrasonography in measurement of fasting and posprandial volume using Bland-Altman plot [ Time Frame: one month ] [ Designated as safety issue: No ]

Enrollment: 36
Study Start Date: October 2007
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
adults
 Other: 3D ultrasound
measurement of stomach volume by 3D ultrasound
2
adolescents
 Other: 3D ultrasound
measurement of stomach volume by 3D ultrasound

Detailed Description:

Specific Aims

  1. To compare the fasting and postprandial volumes measured by 99mTc- SPECT (standard test) and 3-D ultrasound in 12 healthy adults in order to test latter's external validity
  2. To assess the performance characteristics of 3-D ultrasound for the measurement of gastric volumes during fasting and in response to a standard meal, specifically, the intra- and inter-individual coefficient of variation in 12 healthy adults who undergo two estimations of fasting and postprandial volumes
  3. To develop normative data for fasting and postprandial gastric volumes in 24 asymptomatic adolescents.

Study Design

The study will be conducted in 2 parts: first, 12 healthy adults will undergo SPECT and 3-D ultrasound in random order (aim 1); one week after the first ultrasound examination, a second Ultrasound examination will be conducted in all participants (aim 2) In the second part, 24 adolescents (12 in each gender, 12 aged 13-15, 12 aged 16-18)) will undergo a single determination of fasting and postprandial gastric volumes during fasting and post-prandially. The methods and validation of the SPECT study have been previously published (2). Three D ultrasonography will be conducted using state of the art equipment following methods published in the literature. (3)

The study will screen 80 healthy adults or adolescents in order to enroll 12 healthy adulkts for the first two aims, and 24 adolescent healthy subjects for the third aim.

For subjects in group 1, the order of SPECT and 3D- ultrasound tests will be randomized.

The randomization assignments will be made according to a pre-study schedule prepared by the Section of Biostatistics. Medical investigators will be blinded to assignment, allocation will be concealed

  Eligibility

Ages Eligible for Study:   13 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

ealthy adolescents and adults: The study will screen up to 80 healthy adults or adolescents in order to enroll 12 healthy adults for the first two aims, and 24 adolescent healthy subjects for the third aim

Criteria

Inclusion Criteria:

  1. Age: 13-65 years
  2. Body mass index (BMI): 18 to 32 (exept in adolescents)
  3. Negative urine pregnancy test for women of childbearing potential
  4. Absence of gastrointestinal symptoms (abridged Bowel Disease Questionnaire)
  5. Signed informed consent

Exclusion Criteria:

  1. Subjects with body mass index (BMI) of less than 18 or more than 32.
  2. Structural or metabolic diseases/conditions that affect the gastrointestinal system, or functional gastrointestinal disorders. For screening, the Bowel Disease Questionnaire will be used to exclude subjects with irritable bowel syndrome.

  3. Use of drugs or agents within the past 2 weeks that alter GI transit including laxatives, magnesium or aluminum-containing antacids, prokinetics, erythromycin, narcotics, anticholinergics, tricyclic antidepressants, SSRI and newer antidepressants.

    NOTE: Low stable doses of thyroid replacement, estrogen replacement, low dose aspirin for cardioprotection, and birth control pills or depot injections are permissible.

  4. Female subjects who are pregnant or breast feeding.
  5. Females must be either surgically sterilized, postmenopausal (>12 months since last menses) or, if of childbearing potential, using reliable methods of contraception as determined by the physician (single-barrier methods alone and rhythm methods are not acceptable).
  6. Clinical evidence (including physical exam and ECG) of significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric, or other disease that interfere with the objectives of the study. Any candidate participants with such disorder mentioned will be referred to their general physician.
  7. Symptoms of a significant clinical illness in the preceding two weeks.
  8. Participation in another clinical study within the past 30 days.
  9. Subjects who are considered by the investigator to be alcoholics not in remission or known substance abusers.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00588224

Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: Michael L Camilleri, MD Mayo Clinic
  More Information

Additional Information:
Mayo Clinic Clinical Trials  This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party: Michael Camilleri MD, Mayo Clinic
ClinicalTrials.gov Identifier: NCT00588224     History of Changes
Other Study ID Numbers: 07-005231
Study First Received: December 22, 2007
Last Updated: July 20, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by Mayo Clinic:
stomach
accommodation
volume
 SPECT
3 dimensional ultrasonography
healthy volunteers

ClinicalTrials.gov processed this record on May 19, 2013