Modifying Dietary Behavior in Adolescents With Elevated Blood Pressure (DASH-4-Teens)
Recruitment status was Recruiting
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Purpose
The purpose of this study is to examine the long term effects of a 24-week clinically-based behavioral nutrition intervention emphasizing the DASH diet compared to routine nutrition care on changing diet quality, blood pressure, hypertension status, and vascular function in adolescents with elevated blood pressure.
| Condition | Intervention |
|---|---|
|
Hypertension Prehypertension |
Behavioral: DASH-4-Teens Other: Routine Care |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Single Blind (Investigator) Primary Purpose: Treatment |
| Official Title: | Modifying Dietary Behavior in Adolescents With Elevated Blood Pressure |
- Blood Pressure [ Time Frame: immediately post-treatment (6 months) and at 1 year follow-up ] [ Designated as safety issue: No ]
- Vascular Function [ Time Frame: immediately post-treatment (6 months) and at 1 year follow-up ] [ Designated as safety issue: No ]
- Dietary intake [ Time Frame: immediately post-treatment (6 months) and at 1 year follow-up ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 186 |
| Study Start Date: | February 2008 |
| Estimated Study Completion Date: | January 2013 |
| Estimated Primary Completion Date: | September 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: A
DASH-4-Teens Intervention
|
Behavioral: DASH-4-Teens
24-week behavioral nutrition intervention emphasizing a diet high in fruits, vegetables and low fat dairy foods and that is low in fat and sodium
|
|
B
Routine Care
|
Other: Routine Care
individual in-person counseling sessions on guidelines consistent with the Fourth Pediatric Report of the National High Blood Pressure Education Program.
|
Detailed Description:
Hypertension in youth is no longer a rare disease and the number of affected children and adolescents is growing with the evolving pediatric epidemic in the US. Hypertension tracks from adolescence into adulthood and has been linked with preclinical indicators of adverse cardiovascular events in adults. Early prevention and intervention efforts are needed to address this increasing public and individual health problem. Preliminary studies from our research group demonstrate promising short-term effects of a behavioral nutrition intervention emphasizing a diet high in fruits, vegetables and low fat dairy that is also low in fat and sodium (the DASH diet) on lowering blood pressure (BP) in adolescents. The purpose of this application is to extend these findings by examining the long term effects of an improved 24-week clinically based behavioral nutrition intervention emphasizing the DASH diet (the DASH-4-Teens intervention) compared to routine nutrition care intervention on changing diet quality, BP, hypertension status, and vascular function in adolescents with elevated blood pressure. Adolescents with diagnosed pre-hypertension and stage 1 hypertension will be randomly assigned to receive either the DASH-4-teens intervention or routine nutrition care. The DASH-4- Teens intervention will include individual in-person nutrition counseling sessions, behavioral counseling telephone calls, and mailings. Routine nutrition care will include individual in-person counseling sessions on guidelines consistent with the Fourth Pediatric Report of the National High Blood Pressure Education Program. Primary outcomes will be measured in both conditions at 6 months (post-treatment) and at 1 year follow-up. Adherence to treatment will be measured as diet-related goals met, counseling session attendance, and telephone call and food monitoring completion. Findings are expected to improve the treatment of hypertensive adolescents in the clinical setting and contribute to the enhancement of the cardiovascular health of this population.
Eligibility| Ages Eligible for Study: | 11 Years to 18 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- diagnosed pre-hypertension or stage 1 hypertension
- 11-18 years of age
- newly enrolled in the hypertension center at the Cincinnati Children's Hospital Medical Center
Exclusion Criteria:
- stage 2 hypertension
- secondary hypertension
- are being treated with anti-hypertensive medications
- have received prior formalized diet therapy to managed their blood pressure
- have target organ damage (as defined by a left ventricular mass index >51
- diagnosed type 1 or 2 diabetes
- use medications known to alter blood pressure
- are unwilling to stop use of vitamins, minerals or antacids
- do not speak English
- have a diagnosed eating disorder
- have a psychological or medical condition that may preclude them from full participation.
- do not have full medical clearance from a physician to participate
Contacts and Locations| Contact: Sarah C Couch, Ph.D. | 513-558-7504 | Sarah.Couch@uc.edu |
| Contact: Elaine M Urbina, MD | 513-636-1350 | Elaine.Urbina@cchmc.org |
| United States, Ohio | |
| Cincinnati Children's Hospital Medical Center | Recruiting |
| Cincinnati, Ohio, United States, 45229 | |
| Contact: Amy Pflum, M.Ed., RD 513-558-4048 Amy.Pflum@uc.edu | |
| Contact: Sarah C Couch, Ph.D., RD (513) 558-7504 Sarah.Couch@uc.edu | |
| Sub-Investigator: Elaine M Urbina, MD | |
| Principal Investigator: | Sarah C Couch, Ph.D. | University of Cincinnati |
More Information
No publications provided
| Responsible Party: | Sarah C. Couch, University of Cincinnati |
| ClinicalTrials.gov Identifier: | NCT00585832 History of Changes |
| Other Study ID Numbers: | 1R01HL088567-01A1, 1R01HL088567-01A1 |
| Study First Received: | December 27, 2007 |
| Last Updated: | March 23, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Cincinnati:
|
hypertension pre-hypertension adolescents diet vascular function |
Additional relevant MeSH terms:
|
Hypertension Prehypertension Vascular Diseases Cardiovascular Diseases |
ClinicalTrials.gov processed this record on May 23, 2013