Repeatability of X-Ray, MRI, and Gait Analysis - Full Text View

Purpose

The purpose of this preliminary substudy to the parent study "Aerobic Exercise Intervention for Knee Osteoarthritis" is to determine the repeatability and reproducibility of various measurement techniques.

Condition	Intervention
Healthy	Other: Gait analysis, knee x-ray, and knee MRI

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Repeatability of X-Ray, MRI, and Gait Analysis

Resource links provided by NLM:

MedlinePlus related topics: Osteoarthritis X-Rays

U.S. FDA Resources

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:

Day-to-day and inter/intra examiner repeatability of the techniques to be used in NIH grant R01 AR48768 [ Time Frame: Measured two times, with a 1-week period between evaluations ] [ Designated as safety issue: No ]

Estimated Enrollment:	60
Study Start Date:	November 2002
Study Completion Date:	June 2003
Primary Completion Date:	June 2003 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
1 Healthy adult participants with no history of knee injury or osteoarthritis.	Other: Gait analysis, knee x-ray, and knee MRI Gait analysis, knee x-rays, and knee MRIs will be done twice for each participant, 1 week apart.

Detailed Description:

The purpose of this preliminary substudy to the parent study "Aerobic Exercise Intervention for Knee Osteoarthritis" is to determine the repeatability and reproducibility of various measurement techniques. The study will enroll healthy volunteers. All participants will receive x-rays and MRI examinations of the knees. Walking characteristics will be evaluated in a Motion Analysis Lab; this will involve taping reflective markers to participants' skin and having them walk on a level surface and up and down stairs. All participants will be evaluated two times, with a 1-week period between evaluations.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Community sample

Criteria

Inclusion Criteria:

Healthy adults

Exclusion Criteria:

Previous knee injury, knee pain, or knee osteoarthritis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00581841

Locations

United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905

Sponsors and Collaborators

Mayo Clinic

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Investigators

Principal Investigator:

Kenton R. Kaufman, PhD

Mayo Clinic

More Information

Publications:

Schmidt JE, Amrami KK, Manduca A, Kaufman KR. Semi-automated digital image analysis of joint space width in knee radiographs. Skeletal Radiol. 2005 Oct;34(10):639-43. Epub 2005 May 25.

Grochowski SJ, Amrami KK, Kaufman K. Semi-automated digital image analysis of patellofemoral joint space width from lateral knee radiographs. Skeletal Radiol. 2005 Oct;34(10):644-8. Epub 2005 Jul 15.

Koff MF, Amrami KK, Kaufman KR. Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis. Osteoarthritis Cartilage. 2007 Feb;15(2):198-204. Epub 2006 Sep 1.

Agnesi F, Amrami KK, Frigo CA, Kaufman KR. Semiautomated digital analysis of knee joint space width using MR images. Skeletal Radiol. 2007 May;36(5):437-44. Epub 2007 Jan 23.

Responsible Party:	Kenton R. Kaufman, PhD, PE, Mayo Clinic
ClinicalTrials.gov Identifier:	NCT00581841 History of Changes
Other Study ID Numbers:	R01 AR48768 - substudy, R01AR048768, NIAMS-081-1
Study First Received:	December 21, 2007
Last Updated:	May 16, 2013
Health Authority:	United States: Federal Government

Keywords provided by Mayo Clinic:

Healthy adult normals

ClinicalTrials.gov processed this record on May 19, 2013