Metabolism of the Insecticide Permethrin
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Purpose
Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.
| Condition | Intervention |
|---|---|
|
Pharmacokinetics Metabolism |
Other: permethrin insecticide |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Pharmacokinetics Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | CCRC:Identification and Development of Biological Markers of Human Exposure to the Insecticide Permethrin |
- Concentration of individual metabolites in urine [ Time Frame: 192 hours ] [ Designated as safety issue: No ]
- total carbon-14 in serum [ Time Frame: 192 hours ] [ Designated as safety issue: No ]
- Total carbon-14 in saliva [ Time Frame: 192 hours ] [ Designated as safety issue: No ]
- Total carbon-14 in urine samples [ Time Frame: 192 hours ] [ Designated as safety issue: No ]
| Enrollment: | 6 |
| Study Start Date: | February 2006 |
| Study Completion Date: | November 2007 |
-
Other: permethrin insecticide
Permethrin is applied to the forearm of the subject and remains for 8 hours. The exposed area is then washed with soap and water several times. 24 hour urine samples are collected at daily intervals for 192 hours. Blood and saliva samples are taken at pre-dose, 1, 3, 6, 9 12, 24, 48, 72, 96, 120, 144, 168 and 192 hours. Subjects must return to the clinic daily to drop off urine collections and have blood and saliva samples taken.
Eligibility| Ages Eligible for Study: | 18 Years to 50 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- self-report healthy adult men and premenopausal women
Exclusion Criteria:
- unusual alcohol, drug, cigarette use for last 3 years
- unusual exercise program for last 3 years
- under the care of a physician for a disease
- participated in any radioactive drug study
- pregnant
- lactating
- people who rely more on their arm due to illness or injury
- people with neurological or musculoskeletal diseases
- use of permethrin in the last 6 months
- people who apply pesticides as their primary occupation
Contacts and Locations| United States, California | |
| CTSC Research Center | |
| Mather, California, United States, 95655 | |
| Principal Investigator: | Bruce D Hammock, PhD | University of California, Davis |
More Information
No publications provided
| Responsible Party: | Bruce D. Hammock, University of California |
| ClinicalTrials.gov Identifier: | NCT00572884 History of Changes |
| Other Study ID Numbers: | 200311123-8, DAMD17-01-1-0769, P42 ES004699 |
| Study First Received: | December 11, 2007 |
| Last Updated: | December 11, 2007 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of California, Davis:
|
permethrin pyrethroid pharmacokinetics |
metabolism accelerator mass spectrometry human exposure |
Additional relevant MeSH terms:
|
Permethrin Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 19, 2013