Comparison of Systemic Response After Laparoscopies Performed With Standard and Low-Pressure Pneumoperitoneum
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Purpose
The purpose of the study was the comparative assessment of the influence of low and standard pressure CO2 pneumoperitoneum on the systemic inflammatory and angiogenic responses during the postoperative period after laparoscopic management of cholelithiasis.
| Condition |
|---|
|
Laparoscopy. |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | A Comparative Study of Angiogenic and Cytokine Responses After Laparoscopic Cholecystectomy Performed With Standard-Pressure and Low-Pressure Pneumoperitoneum |
- IL-6, IL-8, IL-10, VEGF-A, Endostatin serum levels before the laparoscopies and 6, 24, and 48 h afterwards [ Time Frame: January 2006 - March 2006 ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
serum
| Enrollment: | 40 |
| Study Start Date: | January 2006 |
| Study Completion Date: | March 2006 |
| Groups/Cohorts |
|---|
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I
Patients with cholelithiasis operated on using standard laparoscopy method
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II
Patients with cholelithiasis operated on using low-pressure CO2 pneumoperitoneum laparoscopy
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Detailed Description:
Objective: The purpose of the study was to access the influence of low pressure CO2 pneumoperitoneum on the inflammatory and angiogenic responses during the postoperative period after laparoscopy. Summary background data: Surgical procedures enhance production of pro- and anti-inflammatory cytokines and angiogenic factors that play a pivotal role in the immunological response to surgical trauma and take part in the pathogenesis of tumor growth and adhesions formation. Methods: Study group consisted of 40 patients, operated on due to cholelithiasis using standard- (n=20) and low-pressure (n=20) CO2 pneumoperitoneum. Serum concentration of IL-6, IL-8, IL-10, VEGF-A and endostatin were measured before the surgeries and thereafter at 6, 24 and 48h with commercially available ELISA assays. Results: Concentrations of IL-6 increased significantly after the operations in both groups. No differences were observed between the groups in regards to IL-6, IL-8 and IL-10 levels. Concentrations of VEGF-A measured at 6 and 48h were significantly lower in patients who underwent laparoscopies performed with low pressure pneumoperitoneum. No significant variations were observed in endostatin serum concentration. Concentrations of the studied parameters were not influenced by the duration of surgeries, age, gender, or BMI of the patients. Conclusions: The results obtained in our study do not show any significant differences between studied operative procedures with regards to systemic inflammatory response. Changes in the concentrations of VEGF-A and endostatin observed in the studied population may suggest this technique to be more favorable with regards to angiogenesis process intensity, along with all its consequences and implications.
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
patients with cholelithiasis and indications for surgical treatment; the median age of the patients included in the study was 48,5 and ranged from 18 to 70 years. The ratio of female to male patients was identical within each group and amounted 7:3.
Inclusion Criteria:
- cholelithiasis
Exclusion Criteria:
- symptoms of acute cholecystitis, diabetes, body mass indx above 36 kg/m2 and autoimmunological diseases.
Contacts and Locations More Information
No publications provided
| Responsible Party: | Maciejewski Ryszard, MD, PhD, Medical University of Lublin |
| ClinicalTrials.gov Identifier: | NCT00567125 History of Changes |
| Other Study ID Numbers: | PW 205, PW 205/07 |
| Study First Received: | December 1, 2007 |
| Last Updated: | December 3, 2007 |
| Health Authority: | Poland: Ministry of Health |
Keywords provided by Medical University of Lublin:
|
low-pressure pneumoperitoneum laparoscopy cytokines VEGF-A endostatin |
Additional relevant MeSH terms:
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Pneumoperitoneum Peritoneal Diseases Digestive System Diseases |
ClinicalTrials.gov processed this record on May 19, 2013