Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2014 by Children's Research Institute
Sponsor:
Information provided by (Responsible Party):
D. Ashley Hill, M.D., Children's Research Institute
ClinicalTrials.gov Identifier:
NCT00565903
First received: November 29, 2007
Last updated: September 9, 2014
Last verified: September 2014
  Purpose

Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined. We are working to identify the genetic factors which may contribute to the development of this rare tumor.


Condition
Pleuropulmonary Blastoma
Cystic Nephroma
Sertoli-Leydig Cell Tumor of Ovary
Medulloepithelioma
Embryonal Rhabdomyosarcoma of Cervix

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

Resource links provided by NLM:


Further study details as provided by Children's Research Institute:

Primary Outcome Measures:
  • Identify the genetic factors which contribute to the development or progression of pleuropulmonary blastoma [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Define the clinical features of the pleuropulmonary blastoma (PPB) familial cancer syndrome. [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

We are collecting blood samples or saliva samples. When available, we also collect tumor samples from prior surgical procedures.


Estimated Enrollment: 2000
Study Start Date: March 2005
Estimated Study Completion Date: December 2020
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   up to 95 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Families who have a child or adult with pleuropulmonary blastoma or cystic nephroma are invited to participate.

Criteria

Inclusion Criteria:

  • child or adult diagnosed with pleuropulmonary blastoma or cystic nephroma.

Exclusion Criteria:

  • child or adult who does not have a confirmed diagnosis of pleuropulmonary blastoma or cystic nephroma.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00565903

Contacts
Contact: Dana Ashley Hill, M.D. 202-476-2051 dashleyhill@gmail.com
Contact: Leslie A. Doros, M.D. 202-476-2051 ldoros@childrensnational.org

Locations
United States, District of Columbia
Children's National Medical Center Recruiting
Washington, District of Columbia, United States, 20010
Contact: D Ashley Hill, MD    202-476-2051    dashill@childrensnational.org   
Contact: Leslie Doros, MD    202-476-2051    ldoros@childrensnational.org   
Principal Investigator: Ashley Hill, MD         
Sub-Investigator: Leslie Doros, MD         
Sponsors and Collaborators
D. Ashley Hill, M.D.
Investigators
Study Chair: D. Ashley Hill, MD Children's Research Institute
Study Director: Yoav Messinger, MD Children's Hospital and Clinics of Minnesota
  More Information

Additional Information:
No publications provided

Responsible Party: D. Ashley Hill, M.D., MD, Division Chief Pathology, Children's Research Institute
ClinicalTrials.gov Identifier: NCT00565903     History of Changes
Other Study ID Numbers: 05-0192 / 201012830
Study First Received: November 29, 2007
Last Updated: September 9, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Research Institute:
pleuropulmonary blastoma
PPB
cystic nephroma

Additional relevant MeSH terms:
Rhabdomyosarcoma
Pulmonary Blastoma
Leydig Cell Tumor
Sertoli-Leydig Cell Tumor
Ovarian Neoplasms
Rhabdomyosarcoma, Embryonal
Myosarcoma
Neoplasms, Muscle Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms
Sarcoma
Neoplasms, Complex and Mixed
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Sex Cord-Gonadal Stromal Tumors
Neoplasms, Gonadal Tissue
Testicular Neoplasms
Endocrine Gland Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Genital Diseases, Male
Endocrine System Diseases
Testicular Diseases
Gonadal Disorders
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female

ClinicalTrials.gov processed this record on September 30, 2014