Randomized Controlled Trial Comparing Acellular Collagen Biomesh (Pelvisoft) to Polypropylene Mesh(Pelvitex) for Sacral Colpopexy
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Purpose
This research protocol is a randomized controlled trial. It is being done to compare and find out the relative differences between the materials, (Pelivisoft) "natural organic mesh" to poly propylene mesh (Pelvitex) "manmade mesh" after a surgery known as sacral colpopexy. This surgery involves supporting the prolapsed vaginal wall with a piece of material (known as a graft) attached to a ligament along your backbone (or sacrum). These materials are both FDA approved and widely used. The following objectives: anatomic outcomes, graft-related complications between the two materials, changes in pelvic organ prolapse-related quality of life, subjective changes in sexual function,changes in bowel function and the prolapse related pain present after sacral colpopexy will be evaluated.
The study visits are all under standard of care. Study questionnaires are unique to the study and will be completed at the enrollment in hospital, 2, 6,12 weeks, 6 months and one year visits The questionnaires are related to bowel function, bladder function, prolapse and sexual activity.
Permission will be requested to contact the patient again 5 years after surgery. Contact in the future will in no way obligate the patient to participate.
There may or may not be direct medical benefits to the participant. Decreased risk of erosion may be a possible benefit if placed in the organic "natural" arm of the study. The information learned from this study may benefit other patients in the future
| Condition | Intervention |
|---|---|
|
Uterine Prolapse |
Procedure: sacral colpopexy |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Factorial Assignment Masking: Double Blind (Subject, Outcomes Assessor) Primary Purpose: Treatment |
- anatomic outcomes,graft-related complications between the two materials, changes in pelvic organ prolapse-related quality of life,subjective changes in sexual function,changes in bowel function and the prolapse related pain present after sacral colpopexy [ Time Frame: One year ]
| Enrollment: | 120 |
| Study Start Date: | December 2005 |
| Study Completion Date: | June 2010 |
| Primary Completion Date: | March 2010 (Final data collection date for primary outcome measure) |
-
Procedure: sacral colpopexy
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Greater than 18 years of age
Exclusion Criteria:
- Prior sacral colpopexy or rectopexy
Contraindication to surgery based on co-existent medical condition
Desire for expectant management or pessary use
Pregnancy or the desire for pregnancy within 24 months of the sacral colpopexy procedure
Contacts and Locations| United States, New Jersey | |
| Urogynecology, 95 Madison Ave. | |
| Morristown, New Jersey, United States, 07960 | |
| Principal Investigator: | Patrick Culligan, MD | Atlantic Health Urogynecology |
More Information
No publications provided by Atlantic Health System
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Patrick Culligan MD, Atlantic Health System |
| ClinicalTrials.gov Identifier: | NCT00564083 History of Changes |
| Other Study ID Numbers: | BARD |
| Study First Received: | November 26, 2007 |
| Last Updated: | March 21, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Atlantic Health System:
|
Compare the relative differences between the organic and sythentic materials for sacryl colpopexy. |
Additional relevant MeSH terms:
|
Prolapse Uterine Prolapse Pathological Conditions, Anatomical |
Uterine Diseases Genital Diseases, Female Pelvic Organ Prolapse |
ClinicalTrials.gov processed this record on May 22, 2013