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Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee

This study has been completed.
Sponsor:
Collaborator:
Canadian Institutes of Health Research (CIHR)
Information provided by:
University of Western Ontario, Canada
ClinicalTrials.gov Identifier:
NCT00562822
First received: November 20, 2007
Last updated: November 21, 2007
Last verified: November 2007
History of Changes
  Purpose

The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.


Condition Intervention Phase
Osteoarthritis of the Knee
 Procedure: Arthroscopic surgery
 Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Arthroscopic vs. Non-Surgical Treatment of Osteoarthritis of the Knee

Resource links provided by NLM:

MedlinePlus related topics: Osteoarthritis
U.S. FDA Resources

Further study details as provided by University of Western Ontario, Canada:

Primary Outcome Measures:
  • Function, pain and quality of life based on the WOMAC scores [ Time Frame: 2 years ]

Secondary Outcome Measures:
  • Health utility using the Standard Gamble Technique [ Time Frame: 24 months ]

Enrollment: 188
Study Start Date: January 1999
Study Completion Date: August 2007
Arms Assigned Interventions
Active Comparator: Surgery
Surgery
 Procedure: Arthroscopic surgery
Arthroscopic surgery to treat unresolved symptoms of osteoarthritis of the knee

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Idiopathic or secondary osteoarthritis of the knee with Grade II to IV radiographic severity as defined by the modified Kellgren and Lawrence classification

Exclusion Criteria:

  • Patients with inflammatory or post-infectious arthritis
  • Those who had undergone previous arthroscopic treatment for knee osteoarthritis
  • Those with isolate Grade III to IV medical compartment osteoarthritis with greater than 5 degrees of varus deformity.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00562822

Locations
Canada, Ontario
London Health Sciences Centre - University Hospital
London, Ontario, Canada, N6A 5A5
Sponsors and Collaborators
University of Western Ontario, Canada
Canadian Institutes of Health Research (CIHR)
Investigators
Principal Investigator: Peter J Fowler, MD University of Western Ontario, Canada
Study Chair: Brian G Feagan, MD University of Western Ontario, Canada
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00562822     History of Changes
Other Study ID Numbers: mrc123456, MCT-15227
Study First Received: November 20, 2007
Last Updated: November 21, 2007
Health Authority: Canada: Health Canada

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Arthritis
 Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on May 16, 2013