The Effect of Aging and Immobilisation on Muscle
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Purpose
The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.
| Condition | Intervention |
|---|---|
|
Healthy |
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Basic Science |
| Official Title: | The Effect of Aging and Immobilisation on Muscle |
- muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation [ Time Frame: 2 weeks of immobilisation and 4 weeks of resistance training ]
- single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number [ Time Frame: 2 weeks of imm and 4 weeks of resistance training ]
| Enrollment: | 20 |
| Study Start Date: | January 2007 |
| Study Completion Date: | May 2007 |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
9 healthy elderly males
|
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
|
|
Experimental: 2
11 healthy young males
|
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
|
Eligibility| Ages Eligible for Study: | 20 Years to 80 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)
Exclusion Criteria:
- Musculoskeletal disorder
- Diabetes
- Cardiovascular disease
- Neurological diseases; or
- Cognitive disorders
Contacts and Locations| Denmark | |
| Institute of Sports Medicine, Bispebjerg Hospital | |
| Copenhagen, Denmark, 2400-NV | |
| Principal Investigator: | Charlotte Suetta, MD, PhD | Institute of Sports Medicine Copenhagen, Bispebjerg Hospital |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00559806 History of Changes |
| Other Study ID Numbers: | KF01-322606 |
| Study First Received: | November 15, 2007 |
| Last Updated: | November 15, 2007 |
| Health Authority: | Denmark: National Board of Health |
Keywords provided by Bispebjerg Hospital:
|
immobilisation aging resistance training atrophy The effect of immobilisation in elderly compared to young individuals |
ClinicalTrials.gov processed this record on June 18, 2013