Effects of Dietary Proteins on Hepatic Lipid Metabolism
This study has been completed.
Sponsor:
University of Lausanne
Collaborator:
University Hospital Inselspital, Berne
Information provided by:
University of Lausanne
ClinicalTrials.gov Identifier:
NCT00558740
First received: November 14, 2007
Last updated: February 9, 2012
Last verified: November 2009
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Purpose
Individuals submitted to a high-fat or a high-fructose/sucrose diet develop, over a 6 day-period, several features of the metabolic syndrome, including increased plasma triglycerides, increased intrahepatic lipids, and decreased hepatic insulin sensitivity. It has been recently observed that the increase in intrahepatic lipids observed after a high fat diet is largely prevented when protein intake is concomitantly increased. This suggests that dietary protein protects the liver against some of the deleterious effects of a high fat diet. Mechanisms underlying this effect of protein may include an increased hepatic fat oxidation.
The aims of this study are:
- to evaluate the effects of dietary protein on several major pathways involved in hepatic lipid metabolism ( ketogenesis, lipid oxidation, de novo lipogenesis, VLDL-triglyceride secretion
- to determine whether the decrease in intra-hepatic lipids observed when dietary protein intake is increased are to be attributed to acute or long-term effects of proteins
| Condition | Intervention |
|---|---|
|
Metabolic Syndrome X |
Other: high protein intake |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | Effects of Dietary Proteins on Hepatic Lipid Metabolism |
Resource links provided by NLM:
Further study details as provided by University of Lausanne:
Primary Outcome Measures:
- Whole body lipid oxidation Medium chain triglyceride oxidation Long chain triglyceride oxidation VLDL-triglyceride kinetics Hepatic de novo lipogenesis whole body glucose and glycerol turnover [ Time Frame: acute effects of dietary proteins and after 4 days on a high protein day ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Energy expenditure Glucagon/insulin ratio Plasma growth hormone concentrations gene expression in subcutaneous adipose tissue Plasma ketone bodies concentrations [ Time Frame: acute effects of dietary proteins and after 4 days on a high protein day ] [ Designated as safety issue: No ]
| Enrollment: | 22 |
| Study Start Date: | January 2009 |
| Study Completion Date: | April 2009 |
| Primary Completion Date: | April 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| healthy volunteers |
Other: high protein intake
acute high protein intake chronic (6-day) high protein intake acute+chronic high protein intake control
|
Show Detailed Description Eligibility| Ages Eligible for Study: | 18 Years to 30 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
Healthy volunteers
Criteria
Inclusion Criteria:
- age 18-30
- sex male
- BMI 19-25 kg/m2
- sedentary
- good physical health
Exclusion Criteria:
- family history of diabetes
- use of drugs or illicit substances
- consumption of alcohol >50 g/week
- vegetarians
- smokers
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00558740
Locations
| Switzerland | |
| Centre Hospitalier Universitaire Vaudois | |
| Lausanne, Vaud, Switzerland, CH-1011 | |
Sponsors and Collaborators
University of Lausanne
University Hospital Inselspital, Berne
Investigators
| Principal Investigator: | l Tappy, MD | University of Lausanne |
More Information
No publications provided
| Responsible Party: | Prof. L uc Tappy, Department of Physiology, University of Lausanne |
| ClinicalTrials.gov Identifier: | NCT00558740 History of Changes |
| Other Study ID Numbers: | protocol 66/07/CE/FBM, SNF 310000-109737 |
| Study First Received: | November 14, 2007 |
| Last Updated: | February 9, 2012 |
| Health Authority: | Switzerland: Ethikkommission |
Keywords provided by University of Lausanne:
|
Dietary protein Fructose VLDL-triglycerides Hepatic de novo lipogenesis Lipid oxidation |
Additional relevant MeSH terms:
|
Metabolic Syndrome X Insulin Resistance Hyperinsulinism Glucose Metabolism Disorders Metabolic Diseases |
ClinicalTrials.gov processed this record on May 23, 2013