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Salivary Catecholamines in Aphthous Stomatitis (Canker Sores)

This study has been withdrawn prior to enrollment.
(We are currently modifying the study)
Sponsor:
Information provided by:
University of California, Davis
ClinicalTrials.gov Identifier:
NCT00556686
First received: November 8, 2007
Last updated: June 1, 2011
Last verified: June 2011
History of Changes
  Purpose

The purpose of this study is to examine how compounds produced in patients with canker sores affect wound healing.


Condition
Canker Sore

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Salivary Catecholamines in Aphthous Stomatitis

Resource links provided by NLM:

MedlinePlus related topics: Canker Sores
U.S. FDA Resources

Further study details as provided by University of California, Davis:

Biospecimen Retention:   Samples Without DNA

saliva


Estimated Enrollment: 40
Study Start Date: August 2006
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Individuals with a history of canker sores.
2
Individuals with no history of canker sores.

Detailed Description:

The purpose of this study is to determine if salivary catecholamines are elevated in patients with the disease aphthous stomatitis. The results of this study will be combined with those performed in collaboration with a co-Investigator to understand the effects of catecholamines on mucosal wound healing and oral epithelial cell migration.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

All subjects will be sampled from the community.

Criteria

Inclusion Criteria:

  • Age 18 or older, both genders
  • History of recurrent aphthous ulcers with 4 or more episodes per year

Exclusion Criteria:

  • History of salivary gland disease including Sjogren's disease, parotitis, and sialolithiasis
  • History of benign or malignant salivary gland tumor
  • History of celiac disease, ulcerative colitis or Crohn's disease
  • Patients on medications that affect salivary flow such as anti-depressants and anti-cholinergic medications
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00556686

Sponsors and Collaborators
University of California, Davis
Investigators
Principal Investigator: Nasim Fazel, MD, DDS University of California, Davis
  More Information

Additional Information:
Dermatology Clinical Research  This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party: Nasim Fazel, MD, DDS, University of California Davis
ClinicalTrials.gov Identifier: NCT00556686     History of Changes
Other Study ID Numbers: 200614581
Study First Received: November 8, 2007
Last Updated: June 1, 2011
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Stomatitis
Stomatitis, Aphthous
Mouth Diseases
Stomatognathic Diseases

ClinicalTrials.gov processed this record on June 18, 2013