Inclusion Criteria:

1. Histologically documented metastatic or locally advanced, incurable malignancy for which gemcitabine is clinically appropriate (e.g., non-small cell lung cancer, breast, ovarian, bladder cancer and lymphoma).
2. Male or female patients aged ≥ 18 years old.
3. Maximum of 3 prior regimens in a metastatic setting allowed and may include other targeted agents, immunotherapy and chemotherapy.
4. Measurable disease by RECIST criteria.
5. ECOG PS 0 or 1.

6. Laboratory values as follows:

   • ANC > 1500/μL
   • Hgb > 9 g/dL
   • Platelets >100,000/uL
   • Bilirubin < 1.5 mg/dL
   • AST/SGOT and ALT/SGPT < 2.5 x ULN or < 5.0 x ULN in patients with liver metastases
   • Creatinine < 2.0 mg/dL Or 24-hour Creatinine Clearance > 50 ml/min
   • Albumin > 3 g/dL
   • Potassium > lower limit normal (LLN)
   • Phosphorous > LLN
   • Calcium > LLN
   • Magnesium > LLN

8. Women of childbearing potential must have a negative serum or urine pregnancy test performed within 7 days prior to start of treatment. 9. Life expectancy > 12 weeks. 10. Accessible for treatment and follow-up. 11. All patients must be able to understand the nature of the study and be given written informed consent prior to study entry.

Exclusion Criteria:

1. Prior HDAC, DAC, HSP90 inhibitors or valproic acid for the treatment of cancer. Patients who will need valproic acid for any medical condition during the study or within 5 days prior to first LBH589 treatment

2. Impaired cardiac function including any of the following:

   • Screening ECG with a QTc > 450 msec.
   • Congenital long QT syndrome.
   • History of sustained ventricular tachycardia.
   • Any history of ventricular fibrillation or torsades de pointes.
   • Bradycardia defined as heart rate < 50 beats per minutes. Patients wit a pacemaker and heart rate > 50 beats per minute are eligible.
   • Myocardial infarction or unstable angina within 6 months of study entry.
   • Congestive heart failure (NY Heart Association class III or IV.
   • Right bundle branch block and left anterior hemiblock (bifasicular block).
   • Atrial fibrillation or flutter.
3. Uncontrolled hypertension (systolic blood pressure [BP] 180 or diastolic BP >100mm Hg) or uncontrolled cardiac arrhythmias.
4. Active CNS disease, including meningeal metastases.
5. Known diagnosis of human immunodeficiency virus (HIV) infection.
6. Unresolved diarrhea > CTCAE grade 1.
7. Chemotherapy, investigational drug therapy, major surgery < 4 weeks prior to starting study drug or patients that have not recovered from side effects of previous therapy.
8. Patient is < 5 years free of another primary malignancy except if the other primary malignancy is not currently clinically significant or requiring active intervention, or if other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ. Existence of any other malignant disease is not allowed.
9. Concomitant use of any anti-cancer therapy or radiation therapy other than protocol required gemcitabine.
10. Women who are pregnant or breast feeding or women of childbearing potential (WOCBP) not willing to use a double barrier method of contraception during the study and 3 months after the end of treatment. One of these methods of contraception must be a barrier method. WOCBP are defined as sexually mature women who have not undergone a hysterectomy or who have not been naturally postmenopausal for at least 12 consecutive months (i.e., who has had menses any time in the preceding 12 consecutive months). Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test within 7 days of the first administration of oral LBH589.
11. Male patients whose sexual partners are WOCBP not using a double method of contraception during the study and 3 months after the end of treatment. One of these methods must be a condom.
12. Patients with gastrointestinal (GI) tract disease, causing the inability to take oral medication, malabsorption syndrome, a requirement for intravenous (IV) alimentation, prior surgical procedures affecting absorption, uncontrolled inflammatory GI disease (e.g., Crohn's disease, ulcerative colitis).
13. Other concurrent severe, uncontrolled infection or intercurrent illness, including but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
14. Patients with uncontrolled coagulopathy.
15. Abnormal thyroid function (TSH or free T4) detected at screening. Patients with known hypothyroidism who are stable on thyroid replacement are eligible.