Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS
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Purpose
Correlation between intestinal parasites and serum level of eosinophils and IgE in individuals with HIV or aids attended at clinical hospital of the Botucatu Medical School-UNESP
| Condition |
|---|
|
HIV Infections |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS |
- all [ Time Frame: one year ]
- all [ Time Frame: one year ]
Biospecimen Retention: Samples Without DNA
Sample of Blood Sample of Feces
| Enrollment: | 30 |
| Study Start Date: | March 2007 |
| Study Completion Date: | August 2007 |
| Groups/Cohorts |
|---|
|
1 , 2
those with HIV
|
Detailed Description:
The present study correlates intestinal parasitism and levels of eosonophils and of serum IgEs in patients attended at the C.H. of the School of Medicine - Botucatu/UNESP. Thirty adult patients with AIDS were analyzed in the use of HAART, aged 42 ±11 years, 14 (46.7%) male, excluding those that had used anthelminthics 30 days prior to collection. Socioeconomic questionaires were applied and 3 samples of feces were taken for parasitological exams (TF-test® method) and 5 ml of blood for counting eosinophils (automated hematological counter, Pentra 80, ABX) and IgE doses (equipment BN-100, Dade-Behring). The index of parasites was 10%, with E.nana (3.3%), E.coli (3.3%) and B.hominis (3.3%). Parasitized individuals were from an urban region with complete basic sanitation and good socioeconomic level. Normal eosinphil values were found in all samples and increased IgE values in 1 (33.3%) sample. The index of parasites was low due to good socioeconomic level and disease control. Augmented IgE levels corroborate the literature, which reports an increase characteristic of immune response in the face of parasitic infections in individuals with HIV or AIDS. In conclusion, new studies should be undertaken to evaluate the level of eosinophils associated with cytokines to obtain a better understanding of this correlation.
Eligibility| Ages Eligible for Study: | 18 Years to 60 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
primary care clinic
Inclusion Criteria:
- HIV or AIDS
- age same or superior to 18 years,
- both sexes
- assisted by the Hospital of the Clinics of Botucatu Medical School-UNESP
Exclusion Criteria:
- use of anthelminthic in the period of 30 days antecedents the it dates from collection
- individuals that don't have all of the necessary evaluations to the objectives of the study
- individuals that abandon the attendance, or that you/they are to death during the study
Contacts and Locations
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00546689 History of Changes |
| Other Study ID Numbers: | upeclin/HC/FMB-Unesp-02, Botucatu Medical School UNESP |
| Study First Received: | October 18, 2007 |
| Last Updated: | April 17, 2008 |
| Health Authority: | Brazil: National Committee of Ethics in Research Brazil: National Health Surveillance Agency Brazil: Ministry of Health |
Keywords provided by UPECLIN HC FM Botucatu Unesp:
|
HIV aids intestinal parasites eosinophils |
immunoglobulins HIV/aids Treatment Experienced |
Additional relevant MeSH terms:
|
HIV Infections Acquired Immunodeficiency Syndrome Intestinal Diseases, Parasitic Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral |
Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Parasitic Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases |
ClinicalTrials.gov processed this record on May 22, 2013