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Differential Metabolic Effects of Statins

This study has been completed.
Sponsor:
Information provided by:
Gachon University Gil Medical Center
ClinicalTrials.gov Identifier:
NCT00546559
First received: October 18, 2007
Last updated: August 28, 2008
Last verified: August 2008
History of Changes
  Purpose

The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.


Condition Intervention
Hypercholesterolemia
 Drug: statins (simvastatin, pravastatin)

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Gachon University Gil Medical Center:

Primary Outcome Measures:
  • Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Study Start Date: January 2004
Estimated Study Completion Date: March 2008
  Eligibility

Ages Eligible for Study:   25 Years to 75 Years
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels > 130

Exclusion Criteria:

  • Overt liver disease,
  • Chronic renal failure
  • Hypothyroidism
  • Myopathy
  • Uncontrolled diabetes
  • Severe hypertension
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00546559

Locations
Korea, Republic of
Gil Medical Center
Incheon, Korea, Republic of, 405760
Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00546559     History of Changes
Other Study ID Numbers: GMC-200406
Study First Received: October 18, 2007
Last Updated: August 28, 2008
Health Authority: South Korea: Institutional Review Board

Keywords provided by Gachon University Gil Medical Center:
Lipophilic statins
Insulin resistance
simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Additional relevant MeSH terms:
Hypercholesterolemia
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Simvastatin
Pravastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
 Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Lipid Regulating Agents
Therapeutic Uses
Anticholesteremic Agents
Enzyme Inhibitors

ClinicalTrials.gov processed this record on May 19, 2013