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Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity

This study has been completed.
Sponsor:
Information provided by:
Gachon University Gil Medical Center
ClinicalTrials.gov Identifier:
NCT00546182
First received: October 17, 2007
Last updated: NA
Last verified: October 2007
History: No changes posted
  Purpose

We hypothesized simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients.


Condition
Hypercholesterolemia

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Phase 4 Study of Simvastatin That Affects Insulin Sensitivity

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Gachon University Gil Medical Center:

Primary Outcome Measures:
  • simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients

Study Start Date: January 2004
  Eligibility

Ages Eligible for Study:   25 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Study Population

overweight hypercholesterolemic patients

Criteria

Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels more than 100 and body mass index more than 23.0

Exclusion Criteria:

  • Patients with overt liver disease
  • Chronic renal failure
  • Hypothyroidism, myopathy
  • Uncontrolled diabetes
  • Severe hypertension, stroke
  • Acute coronary events
  • Coronary revascularization within the preceding 3 months, or
  • Alcohol abuse.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00546182

Locations
Korea, Republic of
Gil Medical Center, Gachon University
Incheon, Korea, Republic of, 405760
Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00546182     History of Changes
Other Study ID Numbers: GMC-200405
Study First Received: October 17, 2007
Last Updated: October 17, 2007
Health Authority: Institutional Review Board: Republic of Korea

Keywords provided by Gachon University Gil Medical Center:
Lipophilic statins
Insulin resistance
hypercholesterolemic patients

Additional relevant MeSH terms:
Hypercholesterolemia
Insulin Resistance
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Hyperinsulinism
Glucose Metabolism Disorders
Insulin
Simvastatin
Hypoglycemic Agents
 Physiological Effects of Drugs
Pharmacologic Actions
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Therapeutic Uses
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Enzyme Inhibitors

ClinicalTrials.gov processed this record on June 18, 2013