Rehabilitation for Patients With Pulmonary Arterial Hypertension
Patients suffering from pulmonary arterial hypertension (PAH) frequently remain symptomatic despite medical therapy. Symptoms include breathlessness, poor exercise capacity and reduced quality of life.
In many other serious heart or lung diseases it has been shown that physical rehabilitation improves patient's fitness and quality of life. In PAH there are no clear guidelines and in general physical activity has traditionally been discouraged, although evidence for this advice is lacking. Interesting research project in Germany showed significant benefit for in-patient rehabilitation in PAH patients.
In this study we will perform a controlled clinical study of out-patient rehabilitation of patients with PAH. We hypothesize that physical training of patients will result in increased exercise capacity and improved quality of life.
Pulmonary Arterial Hypertension
Behavioral: Physical training
Behavioral: No training
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
- Six minute walking distance [ Time Frame: 3 months ]
- New York Heart Association (NYHA) functional class [ Time Frame: 3 months ]
- Echocardiographic parameters [ Time Frame: 3 months ]
- Quality of life as assessed by the SF-36 [ Time Frame: 3 months ]
- Performance in cardiopulmonary exercise test [ Time Frame: 3 months ]
|Study Start Date:||February 2008|
Active Comparator: 1
|Behavioral: Physical training|
Placebo Comparator: 2
No physical training
|Behavioral: No training|