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Biochemical Marker to Predict the Recurrence of Atrial Fibrillation After Surgical Maze Procedure

This study has been completed.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00542659
First received: October 10, 2007
Last updated: July 22, 2011
Last verified: July 2011
  Purpose

The role of plasma NT-proBNP, hsCRP, TIMP-1(Tissue inhibitors of MetalloProteinase-1),TGF-b, MMP-3(Matrix MetalloProteinase-3), and pro-MMP-1 in predicting the recurrence of AF after surgical Maze procedure.

The association of expression of CTGF, TGF-b, BNP, ANP, collagen-1, and collagen-3 in LA with the recurrence of AF after surgical Maze procedure.


Condition
Atrial Fibrillation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Plasma ANP and NT-pro-BNP, Atrial Anatomical Change May Determine the Outcome of Maze Operation

Resource links provided by NLM:


Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • AF recurrence [ Time Frame: year ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

plasma mRNA


Estimated Enrollment: 86
Study Start Date: February 2005
Study Completion Date: February 2008
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   30 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation

Criteria

Inclusion Criteria:

  • The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation

Exclusion Criteria:

  • Coronary heart disease
  • Congestive heart failure
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00542659

Locations
Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Young Keun On, MD Samsung Medical Center
  More Information

No publications provided

Responsible Party: Young Keun On, MD, Samsung Medical Center
ClinicalTrials.gov Identifier: NCT00542659     History of Changes
Other Study ID Numbers: 2005-02-019
Study First Received: October 10, 2007
Last Updated: July 22, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Samsung Medical Center:
Atrial fibrillation
Maze procedure

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Cardiovascular Diseases
Heart Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on November 23, 2014