Text Size

Biochemical Marker to Predict the Recurrence of Atrial Fibrillation After Surgical Maze Procedure

This study has been completed.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00542659
First received: October 10, 2007
Last updated: July 22, 2011
Last verified: July 2011
History of Changes
  Purpose

The role of plasma NT-proBNP, hsCRP, TIMP-1(Tissue inhibitors of MetalloProteinase-1),TGF-b, MMP-3(Matrix MetalloProteinase-3), and pro-MMP-1 in predicting the recurrence of AF after surgical Maze procedure.

The association of expression of CTGF, TGF-b, BNP, ANP, collagen-1, and collagen-3 in LA with the recurrence of AF after surgical Maze procedure.


Condition
Atrial Fibrillation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Plasma ANP and NT-pro-BNP, Atrial Anatomical Change May Determine the Outcome of Maze Operation

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • AF recurrence [ Time Frame: year ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

plasma mRNA


Estimated Enrollment: 86
Study Start Date: February 2005
Study Completion Date: February 2008
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   30 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation

Criteria

Inclusion Criteria:

  • The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation

Exclusion Criteria:

  • Coronary heart disease
  • Congestive heart failure
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00542659

Locations
Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Young Keun On, MD Samsung Medical Center
  More Information

No publications provided

Responsible Party: Young Keun On, MD, Samsung Medical Center
ClinicalTrials.gov Identifier: NCT00542659     History of Changes
Other Study ID Numbers: 2005-02-019
Study First Received: October 10, 2007
Last Updated: July 22, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Samsung Medical Center:
Atrial fibrillation
Maze procedure

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on May 19, 2013