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Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2007 by Rudolf Foundation Clinic.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Rudolf Foundation Clinic
ClinicalTrials.gov Identifier:
NCT00533754
First received: September 20, 2007
Last updated: NA
Last verified: September 2007
History: No changes posted
  Purpose

The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.

Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.


Condition Intervention
Age-Related Macular Degeneration
 Procedure: drawing blood

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Rudolf Foundation Clinic:

Primary Outcome Measures:
  • higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals

Secondary Outcome Measures:
  • a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD

Study Start Date: July 2006
Estimated Study Completion Date: November 2007
  Eligibility

Ages Eligible for Study:   55 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • man and women over 18 years old
  • Filled out informed consentBereitschaft zur Teilnahme
  • Diagnosis of non-exudative/ exudative age related macular dgeneneration

Exclusion Criteria:

  • inherited retinal diseases
  • other aquired retinal/ macular
  • missing informed consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00533754

Locations
Austria
Rudoulf foundation Clinic
Vienna, Austria, 1030
Sponsors and Collaborators
Rudolf Foundation Clinic
Investigators
Study Chair: Susanne Binder, M.D. Rudoulf Foundation Clinic
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00533754     History of Changes
Other Study ID Numbers: EK 06-076-VK, EK 06-076-VK
Study First Received: September 20, 2007
Last Updated: September 20, 2007
Health Authority: Austria: Ethikkommission

Keywords provided by Rudolf Foundation Clinic:
age-related macular degeneration, genetics

Additional relevant MeSH terms:
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases

ClinicalTrials.gov processed this record on June 17, 2013