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Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Martin Grossherr, University of Luebeck
ClinicalTrials.gov Identifier:
NCT00532402
First received: September 18, 2007
Last updated: October 29, 2012
Last verified: October 2012
History of Changes
  Purpose

This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor. For comparison a discontinuous method is used. Neurophysiologic parameters for determination of depth of anesthesia are compared to the continuous measured propofol concentration in breathing gas.

Study hypothesis: continuous measured propofol concentration in breathing gas correlates to propofol concentration in plasma and depth of anaesthesia.


Condition
General Anesthesia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas - Compared With Propofol Concentration in Plasma (Before and) After Lung Passage and Neurophysiological Parameters

Resource links provided by NLM:

Drug Information available for: Propofol
U.S. FDA Resources

Further study details as provided by University of Luebeck:

Estimated Enrollment: 16
Study Start Date: September 2007
Study Completion Date: December 2010
  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients having general anesthesia for cardiac and non-cardiac operation

Criteria

Inclusion Criteria:

  • Patient destined for general anesthesia

Exclusion Criteria:

  • Heart insufficiency NYHA IV
  • Allergy to propofol
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00532402

Locations
Germany
Dept. of Anesthesiology , UK-SH, Campus Luebeck
Luebeck, Schleswig-Holstein, Germany, D-23538
Dept. of Anesthesiology, UK-SH, Campus Luebeck
Luebeck, Schleswig-Holstein, Germany, D-23538
Sponsors and Collaborators
University of Luebeck
Investigators
Study Director: Hartmut Gehring, MD, PhD Dept of Anesthesiology, UK-SH, Campus Luebeck
  More Information

Publications:

Responsible Party: Martin Grossherr, Consultant, University of Luebeck
ClinicalTrials.gov Identifier: NCT00532402     History of Changes
Other Study ID Numbers: P-A-S-1
Study First Received: September 18, 2007
Last Updated: October 29, 2012
Health Authority: Germany: Ethics Commission

Keywords provided by University of Luebeck:
Monitoring
Breathing Gas
Propofol

Additional relevant MeSH terms:
Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Propofol
Anesthetics, Intravenous
Anesthetics, General
 Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Hypnotics and Sedatives

ClinicalTrials.gov processed this record on June 17, 2013