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Risk Factors for Recurrent Urinary Tract Infection in Children
This study has been completed.
Sponsored by: Kaunas University of Medicine
Information provided by: Kaunas University of Medicine
ClinicalTrials.gov Identifier: NCT00528476
  Purpose

The purpose of this study is to determine clinical and urodynamic risk factors for recurrent urinary tract infection in 5-18 years old children.


Condition
Urinary Tract Infection
Pyelonephritis
Cystitis

MedlinePlus related topics: Urinary Tract Infections
U.S. FDA Resources
Study Type:
Observational
Study Design:
Natural History, Longitudinal, Case Control, Prospective Study
Official Title:
Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children

Further study details as provided by Kaunas University of Medicine:

Enrollment:
161
Study Start Date:
November 2004
Study Completion Date:
January 2007

Groups/Cohorts
1: Case
Patients, who were treated because of recurrent (2 or more urinary tract infections per year) pyelonephritis or cystitis.
2: Control
Patients with nonrecurrent urinary tract infections (patients who had no history of more than one urinary tract infections in last year).

Detailed Description:

It is known, that in the group of young children the most common reason of recurrent UTI is anatomic abnormalities, such as vesicoureteral reflux, hydronephrosis. However, not all recurrent UTI can be explained by anatomic abnormalities. The vast majority of school age children with recurrent UTI have anatomically normal urinary tract. Recent studies discuss about the role of behavioral and functional abnormalities (inadequate fluid intake, stool retention, infrequent voiding, etc.) that can predispose recurrent urinary tract infections. Influence of some these abnormalities for recurrent UTI is controversial. Family history, behavioral and functional abnormalities which predispose to urinary tract infections in children with normal urinary tract are neglected in most protocols of urinary tract infection.

Children in this study receive a careful evaluation including complete history, voiding-drinking diary, bowel questionnaire, physical investigation, sonography, voiding cystourethrogram.

Follow up time - 1 year. Urinalysis once a month and during each episode of fever.

  Eligibility
Ages Eligible for Study:
5 Years to 18 Years
Genders Eligible for Study:
Both
Accepts Healthy Volunteers:
No
Criteria

Inclusion Criteria:

  • 5-18 years old children, who were treated because of cystitis and pyelonephritis in Kaunas Medical University Hospital

Exclusion Criteria:

  • urinary tract malformations
  • neurogenic bladder dysfunction
  • patients, who received immunosuppressive drugs
  • pregnant girls
  • children with non bacterial urinary tract infection
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00528476

Locations
Lithuania
Kaunas University of Medicine
Kaunas, Lithuania, 44307
Sponsors and Collaborators
Kaunas University of Medicine
Investigators
Principal Investigator: Sarunas Rudaitis, MD Clinic of Children's Diseases, Kaunas University of Medicine
Study Chair: Birute Pundziene, MD, PhD Clinic of Children's Diseases, Kaunas University of Medicine
  More Information

Study ID Numbers:
BE-2-68
First Received:
September 10, 2007
Last Updated:
September 11, 2007
ClinicalTrials.gov Identifier:
NCT00528476  
Health Authority:
Lithuania: State Medicine Control Agency - Ministry of Health

Keywords provided by Kaunas University of Medicine:
pyelonephritis
cystitis
risk factor
children
urodynamics

Study placed in the following topic categories:
Cystocele
Urologic Diseases
Nephritis
Pyelonephritis
Urinary Bladder Diseases
Urinary Tract Infections
Cystitis
Kidney Diseases
Recurrence

Additional relevant MeSH terms:
Communicable Diseases
Nephritis, Interstitial
Infection
Pyelitis

ClinicalTrials.gov processed this record on January 07, 2009