Risk Factors for Recurrent Urinary Tract Infection in Children - Full Text View

Sponsored by:	Kaunas University of Medicine
Information provided by:	Kaunas University of Medicine
ClinicalTrials.gov Identifier:	NCT00528476

Purpose

The purpose of this study is to determine clinical and urodynamic risk factors for recurrent urinary tract infection in 5-18 years old children.

Condition
Urinary Tract Infection Pyelonephritis Cystitis

MedlinePlus related topics: Urinary Tract Infections

U.S. FDA Resources

Study Type:

Observational

Study Design:

Natural History, Longitudinal, Case Control, Prospective Study

Official Title:

Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children

Further study details as provided by Kaunas University of Medicine:

Enrollment:

161

Study Start Date:

November 2004

Study Completion Date:

January 2007

Groups/Cohorts
1: Case Patients, who were treated because of recurrent (2 or more urinary tract infections per year) pyelonephritis or cystitis.
2: Control Patients with nonrecurrent urinary tract infections (patients who had no history of more than one urinary tract infections in last year).

Detailed Description:

It is known, that in the group of young children the most common reason of recurrent UTI is anatomic abnormalities, such as vesicoureteral reflux, hydronephrosis. However, not all recurrent UTI can be explained by anatomic abnormalities. The vast majority of school age children with recurrent UTI have anatomically normal urinary tract. Recent studies discuss about the role of behavioral and functional abnormalities (inadequate fluid intake, stool retention, infrequent voiding, etc.) that can predispose recurrent urinary tract infections. Influence of some these abnormalities for recurrent UTI is controversial. Family history, behavioral and functional abnormalities which predispose to urinary tract infections in children with normal urinary tract are neglected in most protocols of urinary tract infection.

Children in this study receive a careful evaluation including complete history, voiding-drinking diary, bowel questionnaire, physical investigation, sonography, voiding cystourethrogram.

Follow up time - 1 year. Urinalysis once a month and during each episode of fever.

Eligibility

Ages Eligible for Study:

5 Years to 18 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

5-18 years old children, who were treated because of cystitis and pyelonephritis in Kaunas Medical University Hospital

Exclusion Criteria:

urinary tract malformations
neurogenic bladder dysfunction
patients, who received immunosuppressive drugs
pregnant girls
children with non bacterial urinary tract infection

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00528476

Locations

Lithuania
Kaunas University of Medicine
Kaunas, Lithuania, 44307

Sponsors and Collaborators

Kaunas University of Medicine

Investigators

Principal Investigator:	Sarunas Rudaitis, MD	Clinic of Children's Diseases, Kaunas University of Medicine
Study Chair:	Birute Pundziene, MD, PhD	Clinic of Children's Diseases, Kaunas University of Medicine

More Information

Study ID Numbers:

BE-2-68

First Received:

September 10, 2007

Last Updated:

September 11, 2007

ClinicalTrials.gov Identifier:

NCT00528476

Health Authority:

Lithuania: State Medicine Control Agency - Ministry of Health

Keywords provided by Kaunas University of Medicine:

pyelonephritis
cystitis
risk factor
children
urodynamics

Study placed in the following topic categories:

Cystocele
Urologic Diseases
Nephritis
Pyelonephritis
Urinary Bladder Diseases

Urinary Tract Infections
Cystitis
Kidney Diseases
Recurrence

Additional relevant MeSH terms:

Communicable Diseases
Nephritis, Interstitial
Infection
Pyelitis

ClinicalTrials.gov processed this record on January 07, 2009