Biomarker Analysis of Stress

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2007 by National Institute of Environmental Health Sciences (NIEHS).
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00527384
First received: September 6, 2007
Last updated: September 7, 2007
Last verified: September 2007
  Purpose

Physiological changes can occur from different types of stress as induced by an infection, an environmental toxicant exposure, or an emotional disturbance. The stress-induced effects can modify health by lessening defense mechanisms as maintained by the immune system. The ability of different forms of stress to alter physiological processes (body functions) will be assessed by monitoring the blood profile of cell numbers and functions as well as the plasma protein content. It is anticipated that the pattern of blood changes will reflect the types of stress and the degree to which body functions could be altered by the stress.


Condition
Sepsis

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Biomarker Signatures of Biological, Chemical, or Psychological Stress

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 50
Study Start Date: October 2007
Estimated Study Completion Date: May 2011
Detailed Description:

Blood will be collected from patients with an ongoing infection that has lead to sepsis (systemic inflammation) as a index of major stress. The blood will be analyzed for the types of proteins that could alter immune system functions and affect organ functions, including cardiovascular effects due to blood vessel changes. This will be followed by analysis of stress effects on mice and mice that have been generated with human immune cells. The ability of stress to alter blood patterns will also be examined in mice with genetic modification of metallothionein expression, which is believe to influence oxidative stress.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients at Wadsworth Center with Sepsis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00527384

Contacts
Contact: David A. Lawrence, Ph.D. 518-402-5684

Locations
United States, New York
Wadsworth Center Not yet recruiting
Albany, New York, United States, 12201
Sponsors and Collaborators
Investigators
Principal Investigator: David A. Lawrence, Ph.D. Wadsworth Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00527384     History of Changes
Other Study ID Numbers: 16014-CP-001
Study First Received: September 6, 2007
Last Updated: September 7, 2007
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Stress

Additional relevant MeSH terms:
Sepsis
Stress, Psychological
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Behavioral Symptoms

ClinicalTrials.gov processed this record on July 29, 2014