Elevated Serum HDL in Four Generations of a Nashville Family

This study has been terminated.
(Unable to complete enrollment due lack of family interest.)
Sponsor:
Information provided by:
Vanderbilt University
ClinicalTrials.gov Identifier:
NCT00525109
First received: September 4, 2007
Last updated: January 27, 2009
Last verified: January 2009
  Purpose

The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.


Condition Intervention
Hyperlipidemias
Other: No Intervention

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: Elevated Serum HDL in Four Generations of a Nashville Family

Resource links provided by NLM:


Further study details as provided by Vanderbilt University:

Biospecimen Retention:   Samples With DNA

Plasma, Serum, DNA


Estimated Enrollment: 26
Study Start Date: June 2004
Estimated Study Completion Date: June 2009
Groups/Cohorts Assigned Interventions
1
Single family cohort
Other: No Intervention
No intervention
Other Name: No Intervention

Detailed Description:

HDL, or good cholesterol, has been shown to protect against heart attack and stroke. How HDL works as a protective agent is not well understood. There is a family that has 4 generations of living members with high HDL level. In the study, after consent is obtained, we will obtain 2 tablespoons of blood from all the family members in order to study their cholesterol levels and to obtain DNA in order to determine if there is a pattern of inheritance for this trait. We will also have them fill out a questionnaire about their medical history, diet and activity level as all of these can affect their HDL levels. In addition we will obtain additional blood (about 2 tablespoons) for plasma, white blood cells and also perform a biopsy to obtain skin cells from a matched pair of family members with and without the trait in order to determine which genes might be turned on and off because of this trait. We also wish to study other families who have members with high HDL cholesterol as well. These individuals will be identified from a core database.

  Eligibility

Ages Eligible for Study:   5 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Family

Criteria

Inclusion Criteria:

  • 26 living members of a family with HDL levels greater than 90mg/dl and several of whom will act as related age matched controls.
  • The investigators will also identify individuals in a lipid core database with HDL's of greater than 90mg/dl who have normal or low LDL and triglyceride levels and determine if they have normal or low LDL and triglyceride levels and determine if they have family members (parents or siblings) who also have high HDL cholesterol.

Exclusion Criteria:

  • Individuals who are not a member of the study family and individuals with high HDL's and elevated LDL and/or triglycerides.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00525109

Locations
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Vanderbilt University
Investigators
Principal Investigator: Douglas E Vaughan, MD Vanderbilt University
  More Information

No publications provided

Responsible Party: James Muldowney, M.D., Vanderbilt University Medical Center
ClinicalTrials.gov Identifier: NCT00525109     History of Changes
Other Study ID Numbers: 010535
Study First Received: September 4, 2007
Last Updated: January 27, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by Vanderbilt University:
Cholesterol
Hyperlipidemia
Gene array

Additional relevant MeSH terms:
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases

ClinicalTrials.gov processed this record on September 18, 2014