Elevated Serum HDL in Four Generations of a Nashville Family
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.
| Condition | Intervention |
|---|---|
|
Hyperlipidemias |
Other: No Intervention |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Cross-Sectional |
| Official Title: | Elevated Serum HDL in Four Generations of a Nashville Family |
Plasma, Serum, DNA
| Estimated Enrollment: | 26 |
| Study Start Date: | June 2004 |
| Estimated Study Completion Date: | June 2009 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
1
Single family cohort
|
Other: No Intervention
No intervention
Other Name: No Intervention
|
Detailed Description:
HDL, or good cholesterol, has been shown to protect against heart attack and stroke. How HDL works as a protective agent is not well understood. There is a family that has 4 generations of living members with high HDL level. In the study, after consent is obtained, we will obtain 2 tablespoons of blood from all the family members in order to study their cholesterol levels and to obtain DNA in order to determine if there is a pattern of inheritance for this trait. We will also have them fill out a questionnaire about their medical history, diet and activity level as all of these can affect their HDL levels. In addition we will obtain additional blood (about 2 tablespoons) for plasma, white blood cells and also perform a biopsy to obtain skin cells from a matched pair of family members with and without the trait in order to determine which genes might be turned on and off because of this trait. We also wish to study other families who have members with high HDL cholesterol as well. These individuals will be identified from a core database.
Eligibility| Ages Eligible for Study: | 5 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Family
Inclusion Criteria:
- 26 living members of a family with HDL levels greater than 90mg/dl and several of whom will act as related age matched controls.
- The investigators will also identify individuals in a lipid core database with HDL's of greater than 90mg/dl who have normal or low LDL and triglyceride levels and determine if they have normal or low LDL and triglyceride levels and determine if they have family members (parents or siblings) who also have high HDL cholesterol.
Exclusion Criteria:
- Individuals who are not a member of the study family and individuals with high HDL's and elevated LDL and/or triglycerides.
Contacts and Locations| United States, Tennessee | |
| Vanderbilt University Medical Center | |
| Nashville, Tennessee, United States, 37232 | |
| Principal Investigator: | Douglas E Vaughan, MD | Vanderbilt University |
More Information
No publications provided
| Responsible Party: | James Muldowney, M.D., Vanderbilt University Medical Center |
| ClinicalTrials.gov Identifier: | NCT00525109 History of Changes |
| Other Study ID Numbers: | 010535 |
| Study First Received: | September 4, 2007 |
| Last Updated: | January 27, 2009 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Vanderbilt University:
|
Cholesterol Hyperlipidemia Gene array |
Additional relevant MeSH terms:
|
Hyperlipidemias Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases |
ClinicalTrials.gov processed this record on May 19, 2013