Brain Activation During Thermal Stimulation in Neuropathic Pain

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2007 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00525018
First received: September 3, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
  Purpose

Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following peripheral injury, the modulating effect on pain processing in brain by peripheral mechanisms remains elusive. Here, we will systematically compare the sensory symptoms and brain activation to painful heat stimulation applied to the foot dorsum between patients with peripheral neuropathy and healthy controls. Functional magnetic resonance imaging will be used to define brain activation to thermal stimulation with noxious heat and innocuous warm thermal stimuli applied by contact heat stimulator. Brain activation during thermal stimulation in patients with neuropathic pain will be clarified, and we will also analyze the potential relationships between the topography, quality and intensity of the different painful symptoms and the magnitude and pattern of brain activation during thermal stimulation. This will add in our understanding in the pathophysiology of brain modulation in pain and provide clinically useful message toward the potential therapeutics in the management of neuropathic pain.


Condition Intervention
Neuropathic Pain
Device: contact heat evoked potential stimulator

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Brain Activation During Thermal Stimulation in Neuropathic Pain

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 80
Study Start Date: January 2007
Estimated Study Completion Date: July 2008
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   20 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients with peripheral neuropathy (defined according to the neuropathic symptoms and signs) and healthy volunteers will be recruited in this study

Exclusion Criteria:

  • subjects with structural brain lesions, pacemaker implantation, agoraphobia, and neurotic disorders.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00525018

Contacts
Contact: Sung-Tsang Hsieh, MD, PhD 886-2-23123456 ext 8182 sthsieh@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Sung-Tsang Hsieh, MD, PhD    886-2-23123456 ext 8182    sthsieh@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Sung-Tsang Hsieh, MD, PhD Departments of Neurology,National Taiwan University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00525018     History of Changes
Other Study ID Numbers: 9561701022
Study First Received: September 3, 2007
Last Updated: September 3, 2007
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Pain
Functional neuroimaging
Neuropathy
Thermal sensation

Additional relevant MeSH terms:
Neuralgia
Pain
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on April 16, 2014