How to Improve Diagnosis in Infective Endocarditis - Tabular View

Tracking Information

First Received Date ^ICMJE

August 31, 2007

Last Updated Date

February 4, 2009

Start Date ^ICMJE

March 2007

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00524212 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

How to Improve Diagnosis in Infective Endocarditis

Official Title ^ICMJE

Brief Summary

The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).

Detailed Description

Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality.

The variable clinical presentation of IE makes the diagnosis a clinical challenge.

Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections.

The purpose of this study is:

to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected.
to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Other, Prospective

Condition ^ICMJE

Endocarditis, Bacterial

Intervention ^ICMJE

Study Arms / Comparison Groups

Prospective, controlled, blinded study of clinical/TEE criteria of IE compare to clinical/blood test criteria of IE.

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Recruiting

Estimated Enrollment ^ICMJE

600

Estimated Completion Date

January 2009

Primary Completion Date

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Patients > or = 18 year with suspected or verified Infective Endocarditis
By word of mouth or in writing consent

Exclusion Criteria:

Incapacity

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact: Jane B Knudsen, Dr.

+4589496241

KnudsenJB@Gmail.com

Location Countries ^ICMJE

Denmark

Administrative Information

NCT ID ^ICMJE

NCT00524212

Responsible Party

Jane Byriel Knudsen, Dept. of Cardiology, Aarhus University Hospital, Skejby - Denmark

Study ID Numbers ^ICMJE

06-10-B640-A1205-22345, 20060181, SUN-2007-653

Study Sponsor ^ICMJE

University of Aarhus

Collaborators ^ICMJE

Investigators ^ICMJE

Principal Investigator:

Jane B Knudsen, Dr.

Aarhus University Hospital, Skejby, Department of Cardiology, 8200 Aarhus N, Denmark

Information Provided By

University of Aarhus

Verification Date

February 2009

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP