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How to Improve Diagnosis in Infective Endocarditis
This study is currently recruiting participants.
Verified by University of Aarhus, February 2009
First Received: August 31, 2007   Last Updated: February 4, 2009   History of Changes
Sponsored by: University of Aarhus
Information provided by: University of Aarhus
ClinicalTrials.gov Identifier: NCT00524212
  Purpose

The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).


Condition
Endocarditis, Bacterial

Study Type: Observational
Study Design: Prospective

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Estimated Enrollment: 600
Study Start Date: March 2007
Estimated Study Completion Date: January 2009
Groups/Cohorts
A
Prospective, controlled, blinded study of clinical/TEE criteria of IE compare to clinical/blood test criteria of IE.

Detailed Description:

Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality.

The variable clinical presentation of IE makes the diagnosis a clinical challenge.

Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections.

The purpose of this study is:

  • to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected.
  • to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The cohort was selected from all the patients admitted to the tertiary hospital (the initial diagnosis was infective endocarditis)

Criteria

Inclusion Criteria:

  • Patients > or = 18 year with suspected or verified Infective Endocarditis
  • By word of mouth or in writing consent

Exclusion Criteria:

  • Incapacity
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00524212

Contacts
Contact: Jane B Knudsen, Dr. +4589496241 KnudsenJB@Gmail.com

Locations
Denmark
Department of Cardiology, Aarhus University Hospital Recruiting
Aarhus, Denmark, 8200
Contact: Jane B Knudsen, Dr.     89496241     KnudsenJB@Gmail.com    
Sponsors and Collaborators
University of Aarhus
Investigators
Principal Investigator: Jane B Knudsen, Dr. Aarhus University Hospital, Skejby, Department of Cardiology, 8200 Aarhus N, Denmark
  More Information

No publications provided

Responsible Party: Dept. of Cardiology, Aarhus University Hospital, Skejby - Denmark ( Jane Byriel Knudsen )
Study ID Numbers: 06-10-B640-A1205-22345, 20060181, SUN-2007-653
Study First Received: August 31, 2007
Last Updated: February 4, 2009
ClinicalTrials.gov Identifier: NCT00524212     History of Changes
Health Authority: Denmark: Ethics Committee;   Denmark: Danish Dataprotection Agency

Study placed in the following topic categories:
Bacterial Infections
Bacterial Endocarditis
Heart Diseases
Endocarditis, Bacterial
Endocarditis, Infective
Cardiovascular Infections
Infective Endocarditis
Endocarditis

Additional relevant MeSH terms:
Bacterial Infections
Heart Diseases
Endocarditis, Bacterial
Cardiovascular Diseases
Cardiovascular Infections
Infection
Endocarditis

ClinicalTrials.gov processed this record on July 02, 2009