How to Improve Diagnosis in Infective Endocarditis
The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).
|Study Design:||Time Perspective: Prospective|
|Official Title:||Ph. D Student, Jane Byriel Knudsen, Aarhus University|
A venous blood sample was obtained from each patients and all samples were centrifuged and immediately frozen.
|Study Start Date:||March 2007|
|Study Completion Date:||May 2009|
IE confirmed IE rejected
Prospective, controlled, blinded study of clinical/TEE criteria of IE compare to clinical/blood test criteria of IE.
|IE confirmed IE rejected|
Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality.
The variable clinical presentation of IE makes the diagnosis a clinical challenge.
Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections.
The purpose of this study is:
- to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected.
- to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.
|Department of Cardiology, Aarhus University Hospital|
|Aarhus, Denmark, 8200|
|Principal Investigator:||Jane B Knudsen, Dr.||Aarhus University Hospital, Skejby, Department of Cardiology, 8200 Aarhus N, Denmark|