• To evaluate the safety and tolerability of CC-10004, twice per day (BID) for 84 days in subjects with recalcitrant plaque-type psoriasis. [ Time Frame: 84 days ] [ Designated as safety issue: Yes ]
  

• To evaluate the pharmacodynamic(PD)effects of CC-10004 in plaque-type; characterize PK effects and evaluate clinical efficacy;determine the effect on on quality of life [ Time Frame: 84 days of treatment ] [ Designated as safety issue: No ]
  

Inclusion Criteria:

Must understand and voluntarily sign an informed consent form

• Must be male or female subject of any ethnic origin or race that is >18 years at time of consent
• Must have a documented history of plaque-type psoriasis for at least 6 months prior to screening visit

• Subjects must fulfill criteria outlined in at least one of the following clinical categories:

  • Unresponsive to standard systemic therapy, as defined by clinical history, in the investigator's opinion, i.e. inadequate response to one or more adequate treatment course (s) of standard systemic therapy
  • Intolerant to or cannot receive (e.g., contraindication to prescribe) standard systemic therapy or biological interventions for psoriasis
• Must have a sPGA score of at least 3 and a BSA ≥ 10% at screening
• Must meet the specified laboratory criteria:

Must be able to adhere to the study visit schedule and study protocol requirements

• Females of childbearing potential (FCBP)[1] must have a negative urine pregnancy test at screening (Visit 1). In addition, FCBP must agree to use two of the following adequate forms of contraception methods such as oral, injectable, or implantable hormonal contraception; tubal ligation; intrauterine device; barrier contraceptive with spermicide or vasectomized partner while on study. A FCBP must agree to have pregnancy tests every 4 weeks while on study medication.
• Males (including those who have had a vasectomy) must agree to use barrier contraception (latex condoms) when engaging in sexual activity with FCBP

Exclusion Criteria:

History of clinically significant (as determined by the investigator) cardiac, endocrinologic, pulmonary, neurologic, psychiatric, hepatic, renal, hematologic, immunologic, or other major disease

• Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study
• Pregnant or lactating females
• History of active tuberculosis (TB)infection within 3 years prior to the screening visit. Infections which occurred > 3 years prior to entry must have been effectively treated
• History of incompletely treated latent (as indicated by a positive PPD [purified protein derivative] skin results) TB infection
• Clinically significant abnormality on the chest x-ray (CXR) at screening
• Psoriasis flare within 30 days of screening, as defined by protocol
• Use of systemic therapy for psoriasis within 28 days of Visit 2 (Baseline).
• Topical therapy as defined in the protocol Adalimumab, etanercept, efalizumab or infliximab use within 56 days of Visit 2 (Baseline)
• Alefacept use within 180 days of Visit 2 (Baseline)
• Phototherapy (UVA, NB-UVB, PUVA) within 28 days of Visit 2 (Baseline)
• Use of any investigational drug within 28 days of Visit 2 (Baseline), or 5 half lives if known (whichever is longer)Clinically significant abnormality on 12-lead ECG at screening