Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes (ARGARG)
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Purpose
We are conducting a study of asthma patients who use Advair or any other combination of an inhaled corticosteroid (ICS) and a long acting beta agonist (LABA) to manage their asthma symptoms.
Participants begin the study by continuing to use Advair or substituting Advair for their current ICS/LABA medication at their regular dose or the comparable dose(all study medications are provided) for a six-week period. Patients are then separated into 2 groups: one group is asked to use Flovent, the other to use Advair, twice daily over a 16-week period (patients will need to be seen monthly during this time). Neither study personnel nor patients will know which drug is being used.
Patients are also asked to use a peak flow meter and record their daily results on a form, along with the number of puffs they use of their rescue inhaler each day. They also record any changes in asthma medications and information on any asthma episodes.
We hypothesize that there are certain patients with asthma who will do better when a long acting beta agonist is removed from their maintenance asthma medications.
| Condition | Intervention |
|---|---|
|
Asthma |
Drug: fluticasone with salmeterol or fluticasone alone |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | Arg/Arg Genotype and Long Acting Beta Agonists in Asthma. Improved Quality of Care for Patients With Asthma. |
- Primary outcome measure will be absolute change in morning peak flow at the end of the 16-week study period compared with baseline (last two weeks of run-in). [ Time Frame: Outcome will be assessed at the end of the 16-week study period. ] [ Designated as safety issue: No ]
- Absolute and percentage change in rescue inhaler use. [ Time Frame: Outcome wil be assessed at the end of the 16 week study period. ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 100 |
| Study Start Date: | June 2007 |
| Estimated Study Completion Date: | November 2012 |
| Primary Completion Date: | November 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Arm 1 of the study consists of asthma patients who have the Arg/Arg genotype.
|
Drug: fluticasone with salmeterol or fluticasone alone
Randomization will be to fluticasone 45mcg, 115mcg, or 230mcg with salmeterol 21mcg, via HFA device, 2 puffs every 12 hrs, or to fluticasone HFA alone at 44mcg, 110mcg or 220 mcg 2 puffs every 12 hrs, over 16 week study period.
Other Name: Advair HFA and Flovent HFA
|
|
Experimental: 2
Arm 2 of the study consists of patients who have the Gly/Gly phenotype.
|
Drug: fluticasone with salmeterol or fluticasone alone
Randomization will be to fluticasone 45mcg, 115mcg, or 230mcg with salmeterol 21mcg, via HFA device, 2 puffs every 12 hrs, or to fluticasone HFA alone at 44mcg, 110mcg or 220 mcg 2 puffs every 12 hrs, over 16 week study period.
Other Name: Advair HFA and Flovent HFA
|
Detailed Description:
Beta 2 (b2) agonists are the most common type of bronchodilator used to treat asthma. Beta 2 (b2) agonists are agents that bind to b2 receptors and cause muscle relaxation of the airways. There are different variants of the gene (genotypes) that influence how b2 agonists perform among the population.
A recent study demonstrated that patients with mild asthma and the Arg/Arg variant at the 16th amino acid position have improved lung function and asthma control when Proventil, a short acting b2 agonist, is replaced with a different class of bronchodilator. We plan to study asthma patients with distinct genetic makeups of the b2 receptor; specifically Arg/Arg and Gly/Gly.
Throughout the treatment period, patients will be instructed to use Atrovent-HFA (a bronchodilator which works through a different mechanism) for rescue therapy; Proventil-HFA will be available for use if necessary.
The goal of this study is to determine if the withdrawal of a beta 2 agonist leads to improved asthma control in those asthmatic patients with the Arg/Arg genotype compared with those with the Gly/Gly genotype.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age 18 years or older
- History of moderate or severe and persistent asthma
- Currently being treated with a long acting beta agonist and inhaled corticosteroid
- FEV1 > or = 70% at randomization visit (pulmonary function test result)
- Women of childbearing potential must be on an effective form of contraception
- Ability to read and understand English
Exclusion Criteria:
- Active smoking or greater than 10-pack-year history of smoking
- History of intubation for asthma within the past 10 years
- Patients who are pregnant, become pregnant during the study or are breast feeding
- Major comorbidity including: severe cardiac disease, uncontrolled hypertension, poorly controlled diabetes, malignancy within the past 5 years (except non-melanoma skin lesions), and pulmonary disease other than asthma
Contacts and Locations| United States, New Jersey | |
| Hackensack University Medical Center | |
| Hackensack, New Jersey, United States, 07601 | |
| United States, New York | |
| Columbia University Medical Center Eastside | |
| New York, New York, United States, 10022 | |
| Columbia Presbyterian Medical Center | |
| New York, New York, United States, 10032 | |
| Principal Investigator: | Marjorie Slankard, M.D. | Columbia University |
More Information
No publications provided
| Responsible Party: | Marjorie Slankard, Clinical Professor of Medicine, Pulmonary, Columbia University |
| ClinicalTrials.gov Identifier: | NCT00521222 History of Changes |
| Other Study ID Numbers: | AAAC1135 |
| Study First Received: | August 24, 2007 |
| Last Updated: | August 10, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Columbia University:
|
asthma beta agonist bronchodilator pulmonary genotype |
pharmacogenomics corticosteroid allergy immunology |
Additional relevant MeSH terms:
|
Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Salmeterol Fluticasone Adrenergic beta-2 Receptor Agonists Adrenergic beta-Agonists Adrenergic Agonists |
Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Physiological Effects of Drugs Bronchodilator Agents Autonomic Agents Peripheral Nervous System Agents Anti-Asthmatic Agents Respiratory System Agents Therapeutic Uses Dermatologic Agents Anti-Allergic Agents Anti-Inflammatory Agents |
ClinicalTrials.gov processed this record on May 22, 2013