Ghrelin in Older Women

Inclusion Criteria:

Frail group:

• Women aged 70 or greater
• Able to give informed consent
• Undiagnosed weight loss (>5% over the previous year)
• Two of the following four criteria (from Fried L et al, 2001): low grip strength, slow walking speed, subjective exhaustion, low levels of physical activity

Healthy group:

• Women aged 70 or greater
• Able to give informed consent
• None of the frailty criteria

Exclusion Criteria:

• Prior diagnosis of Parkinson's Disease
• History of cerebrovascular accident with residual hemiparesis
• Hospitalization for treatment of vascular disease (including, coronary heart disease, cerebrovascular disease, peripheral vascular disease) in the past 6 months
• Congestive heart failure
• Rheumatoid arthritis or other inflammatory conditions
• Depression (defined as a score of >11 on the Geriatric Depression Questionnaire)
• History of cancer requiring treatment in the past 5 years, with the exception of cancers which have been cured, or, in the opinion of the investigator, carry a good prognosis
• Cognitive deficit as defined by a Folstein Mini Mental State Exam score < 18/30
• Current use of corticosteroids or immune-modulating agents other than topical, ophthalmic, and inhaled preparations, in past 3 months
• Diabetes mellitus
• TSH measured as <0.5mU/L or greater than 10mU/L. If participant is taking replacement thyroid hormone, they should be on a stable dose for at least 2 months
• History of liver disease or abnormal liver function tests (LFTs > 2x upper limit of normal)
• Renal insufficiency (serum creatinine ≥ 1.4 mg/dL).
• Hemoglobin < 11g/dL
• History of surgery within the last 30 days.
• Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study
• Participation in an investigational drug study within 6 weeks prior to screening visit
• Self reported history of HIV disease
• Hospitalization for chronic obstructive pulmonary disease or asthma in the past 3 months

• History of alcohol abuse as defined as any one of the following:

  1) average consumption of 3 or more alcohol containing beverages daily; 2) consumption of 7 or more alcoholic beverages within a 24 hr period in the past 12 months; or 3) clinical assessment of alcohol dependence based on two or more positive responses to the CAGE questionnaire (if confirmed by further probing) or on other evidence available to clinic staff. If any of these exclusion criteria are met, the subject may still be considered eligible if, after an explanation of the importance of limiting alcohol intake during the study, the clinic staff believes that the volunteer can and will limit future alcohol intake to acceptable levels.

• History of gastrectomy
• Current therapy with an appetite stimulant, i.e. medroxyprogesterone acetate, within the last 6 weeks.
• Weight >85 kg