Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial
The purpose of this study is to determine whether celecoxib is effective in the treatment postoperative pain after thyroidectomy.
The research hypothesis:
There is a difference in postoperative morphine consumption in the first 24 hours after thyroidectomy between patients who received celecoxib or placebo.
Cyclooxygenase 2 Inhibitors
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial|
- The patients' total amount of morphine requirement in the first 24 hour. [ Time Frame: 24 hour ] [ Designated as safety issue: Yes ]
|Study Start Date:||August 2007|
|Study Completion Date:||December 2009|
|Primary Completion Date:||December 2009 (Final data collection date for primary outcome measure)|
Placebo Comparator: 2
Other Name: celebrex
No Intervention: 1
Postoperative pain has been concerned in the past few years by both the anesthesiologists ans the surgeons. COX2-inhibitors have played an important roles in postoperative pain with minimal side effects.
Comparison(s): There is a difference in postoperative morphine consumption in the first 24 hours after thyroidectomy between patients who received celecoxib and placebo.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00520338
|Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University|
|Bangkok, Thailand, 10700|
|Principal Investigator:||Sirilak Suksompong, MD||Department of anesthesiology. Siriraj Hospital, Mahidol University, Bangkok, Thailand|