Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

This study is currently recruiting participants.

Verified by Samsung Medical Center, August 2007

First Received: August 13, 2007 No Changes Posted

Sponsor:	Samsung Medical Center
Information provided by:	Samsung Medical Center
ClinicalTrials.gov Identifier:	NCT00516230

Purpose

Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.

Condition
Colonic Neoplasms

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study
Official Title:	Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

Resource links provided by NLM:

Genetics Home Reference related topics: Lynch syndrome

MedlinePlus related topics: Cancer Colorectal Cancer

U.S. FDA Resources

Further study details as provided by Samsung Medical Center:

Estimated Enrollment:	200
Study Start Date:	January 2006
Estimated Study Completion Date:	December 2011

Detailed Description:

Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Colorectal cancer

Exclusion Criteria:

Histology showing other than adenocarcinoma

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00516230

Contacts

Contact: Dong Kyung Chang, M.D. Ph.D	+82-2-3410-3409	dkchang@skku.edu
Contact: Tae Kuen Kim	+82-2-3410-2975	tggo.kim@samsung.com

Locations

Korea, Republic of, Gangnam-gu
Samsung Medical Center	Recruiting
Seoul, Gangnam-gu, Korea, Republic of, 135-710
Contact: Tae Kyun Kim +82-2-3410-2975 tggo.kim@samsung.com

Sponsors and Collaborators

Samsung Medical Center

Investigators

Principal Investigator:

Dong Kyung Chang, M.D. Ph.D

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine

More Information

No publications provided

Study ID Numbers:	SMC-2007-04-080
Study First Received:	August 13, 2007
Last Updated:	August 13, 2007
ClinicalTrials.gov Identifier:	NCT00516230 History of Changes
Health Authority:	South Korea: Institutional Review Board

Keywords provided by Samsung Medical Center:

Colonic Neoplasms
Lynch syndrome

Additional relevant MeSH terms:

Neoplasms
Digestive System Diseases
Neoplasms by Site
Digestive System Neoplasms
Gastrointestinal Diseases
Colonic Diseases

Gastrointestinal Neoplasms
Intestinal Diseases
Rectal Diseases
Colonic Neoplasms
Intestinal Neoplasms
Colorectal Neoplasms

ClinicalTrials.gov processed this record on November 30, 2009