Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2007 by Samsung Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00516230
First received: August 13, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
  Purpose

Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.


Condition
Colonic Neoplasms

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Official Title: Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

Resource links provided by NLM:


Further study details as provided by Samsung Medical Center:

Estimated Enrollment: 200
Study Start Date: January 2006
Estimated Study Completion Date: December 2011
Detailed Description:

Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Colorectal cancer

Exclusion Criteria:

  • Histology showing other than adenocarcinoma
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00516230

Contacts
Contact: Dong Kyung Chang, M.D. Ph.D +82-2-3410-3409 dkchang@skku.edu
Contact: Tae Kuen Kim +82-2-3410-2975 tggo.kim@samsung.com

Locations
Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Gangnam-gu, Korea, Republic of, 135-710
Contact: Tae Kyun Kim    +82-2-3410-2975    tggo.kim@samsung.com   
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Dong Kyung Chang, M.D. Ph.D Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00516230     History of Changes
Other Study ID Numbers: SMC-2007-04-080
Study First Received: August 13, 2007
Last Updated: August 13, 2007
Health Authority: South Korea: Institutional Review Board

Keywords provided by Samsung Medical Center:
Colonic Neoplasms
Lynch syndrome

Additional relevant MeSH terms:
Colonic Neoplasms
Colorectal Neoplasms
Neoplasms
Colonic Diseases
Digestive System Diseases
Digestive System Neoplasms
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Intestinal Diseases
Intestinal Neoplasms
Neoplasms by Site
Rectal Diseases

ClinicalTrials.gov processed this record on October 21, 2014