Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2007 by Samsung Medical Center.
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
Samsung Medical Center
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00516230
First received: August 13, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
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Purpose
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.
| Condition |
|---|
|
Colonic Neoplasms |
| Study Type: | Observational |
| Study Design: | Observational Model: Defined Population Primary Purpose: Screening Time Perspective: Longitudinal Time Perspective: Prospective |
| Official Title: | Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer |
Resource links provided by NLM:
Further study details as provided by Samsung Medical Center:
| Estimated Enrollment: | 200 |
| Study Start Date: | January 2006 |
| Estimated Study Completion Date: | December 2011 |
Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Colorectal cancer
Exclusion Criteria:
- Histology showing other than adenocarcinoma
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00516230
Contacts
| Contact: Dong Kyung Chang, M.D. Ph.D | +82-2-3410-3409 | dkchang@skku.edu |
| Contact: Tae Kuen Kim | +82-2-3410-2975 | tggo.kim@samsung.com |
Locations
| Korea, Republic of | |
| Samsung Medical Center | Recruiting |
| Seoul, Gangnam-gu, Korea, Republic of, 135-710 | |
| Contact: Tae Kyun Kim +82-2-3410-2975 tggo.kim@samsung.com | |
Sponsors and Collaborators
Samsung Medical Center
Investigators
| Principal Investigator: | Dong Kyung Chang, M.D. Ph.D | Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00516230 History of Changes |
| Other Study ID Numbers: | SMC-2007-04-080 |
| Study First Received: | August 13, 2007 |
| Last Updated: | August 13, 2007 |
| Health Authority: | South Korea: Institutional Review Board |
Keywords provided by Samsung Medical Center:
|
Colonic Neoplasms Lynch syndrome |
Additional relevant MeSH terms:
|
Neoplasms Colonic Neoplasms Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms |
Neoplasms by Site Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases Rectal Diseases |
ClinicalTrials.gov processed this record on May 21, 2013