One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators
One-lung ventilation; organ protection; volatile anesthetics
One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:
- Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?
Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.
- Trial with immunomodulatory product / biological
|Study Design:||Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery|
- One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse [ Time Frame: Sep 07 ] [ Designated as safety issue: No ]
|Study Start Date:||October 2004|
|Study Completion Date:||September 2007|
|Primary Completion Date:||September 2007 (Final data collection date for primary outcome measure)|