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Interaction Between Anaesthetics and Methylene Blue

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Geneva
ClinicalTrials.gov Identifier:
NCT00513032
First received: August 7, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
  Purpose

We hypothesized that pre-treatment with methylene blue could potentiate the effects of general anaesthetic agents in patients undergoing parathyroidectomy


Condition Intervention
Hyperparathyroidism
 Drug: methylene blue

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Effects of Methylene Blue on Propofol Requirement During Anaesthesia Induction and Surgery

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital, Geneva:

Enrollment: 22
Study Start Date: January 2005
Study Completion Date: April 2007
Groups/Cohorts Assigned Interventions
Case: methylene blue Drug: methylene blue
5mg.kg-1 methylene blue in 250 ml 5% glucose-saline, administered intravenously approximately 60 min before anaesthesia induction
Control: C Drug: methylene blue
5mg.kg-1 methylene blue in 250 ml 5% glucose-saline, administered intravenously approximately 60 min before anaesthesia induction

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing parathyroidectomy or partial thyroidectomy

Exclusion Criteria:

  • Psychiatric disorders
  • Drug abuse
  • Weight 20% more or less than ideal body weight
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00513032

Locations
Switzerland
Service d'Anesthésiologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest
Geneva, Switzerland, CH-1211
Sponsors and Collaborators
University Hospital, Geneva
Investigators
Principal Investigator: Marc Licker, MD University Hospital, Geneva
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00513032     History of Changes
Other Study ID Numbers: 02-081(02-006)
Study First Received: August 7, 2007
Last Updated: August 7, 2007
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital, Geneva:
propofol
anaesthesia induction
parathyroidectomy
methylene blue
General anesthesia

Additional relevant MeSH terms:
Hyperparathyroidism
Parathyroid Diseases
Endocrine System Diseases
Anesthetics
Methylene Blue
Central Nervous System Depressants
 Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on May 19, 2013