Ghrelin Decreases Insulin Sensitivity
Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.
|Study Design:||Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Health Services Research
|Official Title:||Intravenous Ghrelin Infusion Decreases Insulin Sensitivity in Healthy Young Men|
- Insulin sensitivity [ Time Frame: End of clamp period ] [ Designated as safety issue: No ]
- Effects on lipolysis [ Time Frame: End of basal and end og clamp period ] [ Designated as safety issue: No ]
|Study Start Date:||January 2003|
|Study Completion Date:||October 2003|
|Primary Completion Date:||October 2003 (Final data collection date for primary outcome measure)|
|Placebo Comparator: 2||
Drug: Ghrelin and saline (as placebo)
The current study is initiated in order to assess the impact of acute ghrelin administration on insulin resistance measured by a hyperinsulinemic euglycemic clamp. Second, as free fatty acid is the predominant substrate during fasting, we aim to asses the effects of ghrelin on local and systemic lipolysis.