Complex Problem Solving Training in Schizophrenic Patients

This study has been completed.
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by:
Heidelberg University
ClinicalTrials.gov Identifier:
NCT00507988
First received: July 25, 2007
Last updated: May 14, 2009
Last verified: May 2009
  Purpose

The primary purpose of the study is to assess whether a planning and problem-solving training is more effective in improving work therapy performance in patients with schizophrenia than traditional training programs addressing basic cognitive functions.


Condition Intervention
Schizophrenia
Schizoaffective Disorder
Behavioral: Complex Problem Solving Training
Behavioral: Basic Cognitive Training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Complex Problem Solving Training in Schizophrenic Patients

Resource links provided by NLM:


Further study details as provided by Heidelberg University:

Primary Outcome Measures:
  • Functional Capacity as assessed by Osnabrücker Arbeitsfähigkeitsprofil "learning ability" subscale [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Functional Capacity as assessed by the Osnabrücker-Arbeitsfähigkeitsprofil summary score [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • BADS Zoo Map Score (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • Planungstest (Tower of London) Summary Score (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • Plan-A-Day S Solution Time (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Enrollment: 91
Study Start Date: August 2007
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A
Complex Problem Solving Training
Behavioral: Complex Problem Solving Training
10 sessions of 45 minutes complex problem solving training over 3 weeks (including 30 minutes of computerized planning and problem-solving training with Plan-A-Day and 15 minutes group session for transfer to everyday situations)
Active Comparator: B
Basic Cognitive Training
Behavioral: Basic Cognitive Training
10 sessions over 3 weeks of 45 min basic cognitive training (including 45 min computerized training of attention, processing speed, memory)

Detailed Description:

In patients with schizophrenia, cognitive deficits often lead to an impairment in daily life. This observation has led to the development of cognitive training packages aiming a improving these deficits. However, it is far from clear which level of cognitive functioning provides the best target for cognitive interventions. Traditionally, training has aimed a basic cognitive functions like attention and memory. In the present study we aim at a higher-level of function, namely planning and problem-solving skills, which are trained using the software package Plan-A-Day. The primary hypothesis is that complex problem solving training improved functional capacity more than traditional training programs addressing basic cognitive function.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with schizophrenic or schizoaffective Disorder (DSM IV)
  • Remitted positive symptoms (PANSS positive all ≤ 4), clinical stability
  • Native German speaker
  • Verbal IQ > 80
  • Visual acuity normal or corrected to normal

Exclusion Criteria:

  • Concurrent Axis-I disorder
  • Drug abuse during last 2 months
  • Neurological or medical conditions potentially affecting cognition
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00507988

Locations
Germany
SRH Klinikum Karlsbad-Langensteinbach
Karlsbad, Germany, 76307
Sponsors and Collaborators
Heidelberg University
German Federal Ministry of Education and Research
Investigators
Principal Investigator: Matthias Weisbrod, MD SRH Klinikum Karlsbad-Langensteinbach, Department of Psychiatry
  More Information

No publications provided by Heidelberg University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Irmtraut Gürkan, University Hospital Heidelberg
ClinicalTrials.gov Identifier: NCT00507988     History of Changes
Other Study ID Numbers: 01GW0630
Study First Received: July 25, 2007
Last Updated: May 14, 2009
Health Authority: Germany: Ethics Commission

Keywords provided by Heidelberg University:
Cognitive Training
Complex Problem Solving
Goal Management
Planning

Additional relevant MeSH terms:
Psychotic Disorders
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on April 17, 2014