Complex Problem Solving Training in Schizophrenic Patients

This study has been completed.
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by:
Heidelberg University
ClinicalTrials.gov Identifier:
NCT00507988
First received: July 25, 2007
Last updated: May 14, 2009
Last verified: May 2009
  Purpose

The primary purpose of the study is to assess whether a planning and problem-solving training is more effective in improving work therapy performance in patients with schizophrenia than traditional training programs addressing basic cognitive functions.


Condition Intervention
Schizophrenia
Schizoaffective Disorder
Behavioral: Complex Problem Solving Training
Behavioral: Basic Cognitive Training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Complex Problem Solving Training in Schizophrenic Patients

Resource links provided by NLM:


Further study details as provided by Heidelberg University:

Primary Outcome Measures:
  • Functional Capacity as assessed by Osnabrücker Arbeitsfähigkeitsprofil "learning ability" subscale [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Functional Capacity as assessed by the Osnabrücker-Arbeitsfähigkeitsprofil summary score [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • BADS Zoo Map Score (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • Planungstest (Tower of London) Summary Score (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • Plan-A-Day S Solution Time (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Enrollment: 91
Study Start Date: August 2007
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A
Complex Problem Solving Training
Behavioral: Complex Problem Solving Training
10 sessions of 45 minutes complex problem solving training over 3 weeks (including 30 minutes of computerized planning and problem-solving training with Plan-A-Day and 15 minutes group session for transfer to everyday situations)
Active Comparator: B
Basic Cognitive Training
Behavioral: Basic Cognitive Training
10 sessions over 3 weeks of 45 min basic cognitive training (including 45 min computerized training of attention, processing speed, memory)

Detailed Description:

In patients with schizophrenia, cognitive deficits often lead to an impairment in daily life. This observation has led to the development of cognitive training packages aiming a improving these deficits. However, it is far from clear which level of cognitive functioning provides the best target for cognitive interventions. Traditionally, training has aimed a basic cognitive functions like attention and memory. In the present study we aim at a higher-level of function, namely planning and problem-solving skills, which are trained using the software package Plan-A-Day. The primary hypothesis is that complex problem solving training improved functional capacity more than traditional training programs addressing basic cognitive function.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with schizophrenic or schizoaffective Disorder (DSM IV)
  • Remitted positive symptoms (PANSS positive all ≤ 4), clinical stability
  • Native German speaker
  • Verbal IQ > 80
  • Visual acuity normal or corrected to normal

Exclusion Criteria:

  • Concurrent Axis-I disorder
  • Drug abuse during last 2 months
  • Neurological or medical conditions potentially affecting cognition
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00507988

Locations
Germany
SRH Klinikum Karlsbad-Langensteinbach
Karlsbad, Germany, 76307
Sponsors and Collaborators
Heidelberg University
German Federal Ministry of Education and Research
Investigators
Principal Investigator: Matthias Weisbrod, MD SRH Klinikum Karlsbad-Langensteinbach, Department of Psychiatry
  More Information

No publications provided by Heidelberg University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Irmtraut Gürkan, University Hospital Heidelberg
ClinicalTrials.gov Identifier: NCT00507988     History of Changes
Other Study ID Numbers: 01GW0630
Study First Received: July 25, 2007
Last Updated: May 14, 2009
Health Authority: Germany: Ethics Commission

Keywords provided by Heidelberg University:
Cognitive Training
Complex Problem Solving
Goal Management
Planning

Additional relevant MeSH terms:
Psychotic Disorders
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on August 20, 2014