2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides
To compare the clinical efficacy and systemic side effects between 2.5% and 10% phenylephrine for mydriasis in diabetic patient with darkly pigmented irides.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Diagnostic
|Official Title:||2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides|
- Pupil diameters were measured. [ Time Frame: before and after phenylephrine eye drop instillations ] [ Designated as safety issue: No ]
- blood pressure and heart rate were measured [ Time Frame: before and after phenylephrine eye drop instillations ] [ Designated as safety issue: Yes ]
|Study Start Date:||May 2007|
|Study Completion Date:||July 2007|
One hundred patients with diabetes from Srinagarind Hospital Eye Clinic were enrolled and randomized into two groups by block randomization. In group I (50 patients), 1% tropicamide combined with 2.5% phenylephrine were administered to dilate pupil whereas 1% tropicamide combined with 10% phenylephrine were used in Group II (50 patients). Pupil diameter, blood pressure and heart rate were measured before and after eye drop instillations.