Effects of Growth Hormone on Exercise Capacity
The purpose of this study was to assess whether Growth Hormone(GH)improves exercise capacity and cardiopulmonary performance in patients with chronic heart failure.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Effects of Growth Hormone on Exercise Capacity and Cardiopulmonary Performance in Patients With Chronic Heart Failure|
- The primary outcome of the study was improvement of peak VO2 assessed by a cardiopulmonary exercise testing. [ Time Frame: three months ]
- Secondary endpoints were exercise capacity and ejection fraction obtained by echocardiography. [ Time Frame: three months ]
|Study Start Date:||November 1997|
|Study Completion Date:||November 2005|
clinical studies have focused the effects of GH on left ventricular function and hemodynamics. Little is known about the impact of GH on cardiopulmonary performance and exercise capacity. Such data would be relevant, given the well-recognized importance of cardiopulmonary performance and exercise capacity as markers of disease progression and predictors of mortality in patients with CHF.Consequently we conducted a randomised double blind placebo controlled trial to investigate the effects of a three month course of GH, adjunctive to background therapy, on cardiopulmonary performance and exercise capacity in patients with dilated cardiomyopathy and CHF.The primary outcome of the study was improvement of peak VO2 assessed by a cardiopulmonary exercise testing. Secondary endpoints were exercise capacity and ejection fraction obtained by echocardiography.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00501514
|Dpt of internal medicine University Federico II|
|Naples, Italy, 80131|
|Principal Investigator:||Luigi Saccà, MD||Federico II University|