Predictors of Treatment Outcome for Smokers With and Without Schizophrenia
The primary purpose of this investigation is to determine the predictive value of task persistence as measured by a mirror tracing task. A secondary purpose is to evaluate differences in task persistence in smokers with or without schizophrenia. It is hypothesized that task persistence in smokers in both diagnostic categories (schizophrenia and no schizophrenia) will predict tobacco dependence treatment outcome at one and six months. It is also hypothesized that smokers with schizophrenia will show lower levels of task persistence after controlling for other motor skills than smokers without schizophrenia.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Predictors of Treatment Outcome for Smokers With and Without Schizophrenia|
- Mirror-tracing Persistence (in Seconds) [ Time Frame: baseline ] [ Designated as safety issue: No ]Number of seconds participants continued working on a mirror tracing task before giving up.
- Persistence as a Prospective Predictor of Smoking Cessation [ Time Frame: 6 months ] [ Designated as safety issue: No ]Analysis of Generalized Estimating Equations (GEE) parameter estimates based on empirical standard error estimates, using an exchangeable working correlation structure, with smoking abstinence as outcome variable, and task persistence, time, diagnosis, ability, Fagerstrom Test for Nicotine Dependence (FTND) score, and the interaction between disorder and persistence as explanatory variables.
|Study Start Date:||February 2005|
|Study Completion Date:||January 2013|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Smokers not meeting criteria for Schizophrenia or Schizoaffective Disorder
Smokers with Schizophrenia
Smokers meeting criteria for schizophrenia or schizoaffective disorder
Please see brief summary above.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00501007
|United States, New Jersey|
|UMDNJ Tobacco Dependence Clinic|
|New Brunswick, New Jersey, United States, 08901|
|Principal Investigator:||Marc L. Steinberg, PH.D||Rutgers, The State University of New Jersey|