A Study of MLN8237, a Novel Aurora A Kinase Inhibitor, in Patients With Advanced Solid Tumors

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Millennium Pharmaceuticals, Inc.
ClinicalTrials.gov Identifier:
NCT00500903
First received: July 12, 2007
Last updated: November 15, 2013
Last verified: November 2013
  Purpose

To determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of MLN8237 when given by mouth (PO) for a minimum of 7 and a maximum of 21 consecutive days, followed by a 14-day recovery period.


Condition Intervention Phase
Advanced Malignancies
Drug: MLN8237
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: An Open-Label, Dose Escalation Phase 1 Study of MLN8237, a Novel Aurora A Kinase Inhibitor, in Patients With Advanced Solid Tumors

Resource links provided by NLM:


Further study details as provided by Millennium Pharmaceuticals, Inc.:

Primary Outcome Measures:
  • determine the dose-limiting toxicity of MLN8237 [ Time Frame: Duration of therapy ] [ Designated as safety issue: Yes ]
  • determine the maximum tolerated dose of MLN8237 [ Time Frame: Duration of therapy ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • describe the pharmacokinetics of MLN8237 [ Time Frame: Duration of therapy ] [ Designated as safety issue: Yes ]
  • evaluate the relationship between MLN8237 exposure and inhibition of Aurora A kinase in the proliferating basal epithelial cells of the skin [ Time Frame: Duration of therapy ] [ Designated as safety issue: Yes ]
  • estimate the effect of food on the PK of MLN8237 [ Time Frame: Duration of therapy ] [ Designated as safety issue: Yes ]
  • describe any antitumor activity that may be observed with MLN8237 treatment [ Time Frame: Duration of therapy ] [ Designated as safety issue: Yes ]

Enrollment: 87
Study Start Date: May 2007
Study Completion Date: November 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
MLN8237
Drug: MLN8237
MLN8237 will be supplied in capsules of 5 or 25 mg and will be given on an empty stomach, with patients remaining nothing by mouth except for water and prescribed medications for 2 hours before and 1 hour after each dose. Each dose will be given by mouth with 8 ounces of water for 7 to 21 consecutive days. A 14-day recovery period will follow each dosing period regardless of its duration.

Detailed Description:

This is an open-label, multicenter, dose escalation, phase 1 study of MLN8237 in adult patients with advanced solid tumors. This study will be the first to administer MLN8237 to humans. MLN8237 will be given daily for 7 to 21 consecutive days followed by a 14-day recovery period (cycle length = 21 to 35 days). Patients will continue to receive repeated cycles of MLN8237 as long as their disease has not progressed and they have not experienced unacceptable MLN8237-related toxicity. The dose of MLN8237 will be increased in successive cohorts of 3 to 6 patients until a maximum tolerated dose of MLN8237 has been identified. Once a maximum tolerated dose has been identified for 7 consecutive days of treatment, a total of 9 to 12 patients will be treated at that dose to better define its safety, PK, and pharmacodynamics. Longer periods of dosing with MLN8237 then will be evaluated, with an increase from 7 to 14 days, and, if feasible, to 21 days. Intermediate lengths of dosing may also be evaluated. A 14-day recovery period will follow each dosing period regardless of its duration.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Histologically or cytologically confirmed metastatic and/or advanced solid tumors (including lymphomas) for which no effective standard treatment is available
  • Aged 18 years or more
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
  • Expected survival longer than 3 months from enrollment in the study
  • Radiographically or clinically evaluable tumor; however, measurable disease as defined by RECIST criteria is not required for participation in this study
  • Suitable venous access for the conduct of blood sampling for MLN8237 PK
  • Recovered from the reversible effects of prior antineoplastic therapy (with the exception of alopecia and grade 1 neuropathy) with at least 4 weeks elapsed since the last exposure to cytotoxic chemotherapy or to radiotherapy and at least 6 weeks elapsed since exposure to nitrosoureas or mitomycin C. Patients treated with fully human monoclonal antibodies must not have received treatment with such antibodies for at least 6 weeks, and those treated with chimeric monoclonal antibodies must not have received treatment with such antibodies for at least 4 weeks. Patients treated with noncytotoxic small molecule drugs (eg, tyrosine kinase inhibitors, such as Tarceva®, and hormonal agents, such as Femara®) must not have received treatment with these drugs for at least 2 weeks before the first dose of MLN8237 is given.
  • Male patients must use an appropriate method of barrier contraception (eg, condoms) and inform any sexual partners that they must also use a reliable method of contraception (eg, birth control pills) from the time of informed consent until 3 months after the last dose of study treatment.
  • Female patients must be postmenopausal, surgically sterilized, or willing to use reliable methods of birth control (eg, a hormonal contraceptive, an intrauterine device, diaphragm with spermicide, or abstinence) and inform male sexual partners that they must also use a reliable method of contraception (eg, condoms) from the time of informed consent until 3 months after the last dose of study treatment.
  • Willing and able to give written informed consent before the conduct of any study related procedure that is not part of normal medical care, and willing to comply with the protocol

Exclusion Criteria:

  • Pregnant or lactating
  • Major surgery or serious infection within the 28 days preceding the first dose of study treatment
  • Life-threatening illness or uncontrolled medical illness unrelated to cancer
  • Ongoing nausea or vomiting of any severity
  • > Grade 1 diarrhea
  • Known GI disease or GI procedure that could interfere with the oral absorption or tolerance of MLN8237. Examples include but are not limited to partial gastrectomy, history of small intestine surgery, and celiac disease.
  • History of uncontrolled sleep apnea syndrome and other conditions that could result in excessive daytime sleepiness, such as severe chronic obstructive pulmonary disease.
  • Difficulty swallowing capsules
  • Inability to take nothing by mouth except for water and prescribed medications for 2 hours before and 1 hour after each dose of MLN8237
  • Received more than 4 previous cytotoxic chemotherapeutic regimens including regimens used as adjuvant or neo-adjuvant therapies. There is no limit on the number of noncytotoxic therapies (eg, hormonal and immunologic) that patients may have received. Tyrosine kinase inhibitors (eg, Tarceva and Iressa®) are considered noncytotoxic compounds.
  • Prior treatment with high-dose chemotherapy, defined as chemotherapy requiring the use of peripheral blood or bone marrow stem cell support for hematopoietic reconstitution
  • Prior treatment with radiation therapy involving ≥25% of the hematopoietically active bone marrow
  • Clinical and/or radiographic evidence of cerebral metastases. However, patients who have a history of central nervous system (CNS) metastasis but who have no radiographic or clinical evidence of residual tumor (eg, following complete surgical resection or stereotactic radiosurgery) are not excluded from participation in this study
  • Absolute neutrophil count <1500/mm3; platelet count <100,000/mm3
  • Serum creatinine >1.6 mg/dl or a measured or estimated creatinine clearance <40 mL/minute
  • Bilirubin >1.5 times the upper limit of the normal range (ULN); aspartate aminotransferase (AST)/alanine aminotransferase (ALT) >2.5 times the ULN, and alkaline phosphatase (ALP) >2.5 times the ULN. Both the AST and ALP may be elevated up to 5 times the ULN if their elevation can be reasonably ascribed to the presence of metastatic disease to liver and/or to bone; however, the ALT must in all circumstances be <2.5 times the ULN
  • Abnormalities on 12-lead electrocardiogram (ECG) considered by the investigator to be clinically significant or baseline prolongation of the rate-corrected QT interval (eg, repeated demonstration of QTc interval > 450 milliseconds)
  • Left ventricular ejection fraction (LVEF) < 50%
  • Known or suspected human immunodeficiency virus (HIV) positive or hepatitis B surface antigen-positive status, or known or suspected active hepatitis C infection.

Testing for these agents is not required in the absence of clinical findings or suspicion.

  • Less than 4 weeks between the last dose of an investigational agent and the first dose of MLN8237
  • Admission or evidence of benzodiazepine dependence or abuse and/or alcohol abuse or an inability to restrict consumption of alcohol to no more than 1 standard unit of alcohol per day during the study and for 30 days from the last dose of study treatment. A standard unit of alcohol is defined as one 12-oz (150mL) beer, 1.5 oz (45mL) of 80-proof alcohol, or one 6-oz (175mL) glass of wine.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00500903

Locations
United States, Tennessee
Sarah Cannon Research Institute (SCRI)
Nashville, Tennessee, United States, 37203
Sponsors and Collaborators
Millennium Pharmaceuticals, Inc.
Investigators
Study Director: Medical Monitor Millennium Pharmaceuticals, Inc.
  More Information

No publications provided

Responsible Party: Millennium Pharmaceuticals, Inc.
ClinicalTrials.gov Identifier: NCT00500903     History of Changes
Other Study ID Numbers: C14001
Study First Received: July 12, 2007
Last Updated: November 15, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by Millennium Pharmaceuticals, Inc.:
Advanced malignancies

Additional relevant MeSH terms:
Neoplasms

ClinicalTrials.gov processed this record on August 28, 2014