Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study (MMS)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2007 by Technische Universität München.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Ludwig-Maximilians - University of Munich
Information provided by:
Technische Universität München
ClinicalTrials.gov Identifier:
NCT00500773
First received: July 11, 2007
Last updated: NA
Last verified: July 2007
History: No changes posted
  Purpose

The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. We aim to investigate the beneficial effects of regular well-dosed exercise on health and compare these findings with the effects of the extreme strains of marathon running. Subclinical injuries to heart and arteries are being investigated in different groups of runners, including obese participants.


Condition
Modes of Exercise and Myocardial and Endothelial Function
Microcirculation
Subclinical Endorgan Damage
Obesity

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Investigation of Myocardial Injury, Ventricular Dysfunction and Cardiovascular Risk Factors in Different Groups of Marathon Runners

Resource links provided by NLM:


Further study details as provided by Technische Universität München:

Enrollment: 60
Study Start Date: July 2007
Estimated Study Completion Date: September 2007
Detailed Description:

Regular exercise leads to an improvement of cardiovascular risc factors in patients with coronary heart disease, atherosclerosis and metabolic disorders. Aerobic exercise has anti-inflammatory effects. In contrast, the exertional exercise of marathon running causes an acute pro-inflammatory impulse. This may lead to myocardial injury and, in case of preexisting plaques, may result in plaque rupture and acute myocardial infarction.

We aim to define the critical role of inflammatory markers and cardiovascular risc factors as a predictor of an increased risc for myocardial and endothelial dysfunction in marathon runners.

The study groups are divided into average trained runners (40 km/week), average trained obese runners and highly trained runners (> 70km/week). Training programmes are supervised by professional coaches. Individual scientific marathon contests are organized for the assessments.

Diagnostic tools include measurements of pulse wave velocity and heart rate turbulence, echocardiography and, for the first time, MRI-scans pre- and post marathon running. Additionally, cardiovascular markers such as endothelial progenitor cells(EPCs)and adiponectin are measured. Inflammatory markers include c-reactive protein (CRP), interleukins and tumor necrosis factor.

  Eligibility

Ages Eligible for Study:   30 Years to 60 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Men aged 30-60 years
  • Obese subjects: BMI > 27 and waist circumference > 102cm

Exclusion Criteria:

  • manifested heart disease
  • insulin dependent diabetes mellitus
  • multiple drug therapy
  • GFR < 60 ml/min.
  • claustrophobia
  • metal implants
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00500773

Locations
Germany
Department of Prevention and Sportsmedicine, Technical University of Munich
Connollystrasse 32, Munich, Bavaria, Germany, 80809
Sponsors and Collaborators
Technische Universität München
Ludwig-Maximilians - University of Munich
Investigators
Principal Investigator: Henner Hanssen, MD Department of Prevention and Sportmedicine, Technical University Munich
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00500773     History of Changes
Other Study ID Numbers: 1807/07
Study First Received: July 11, 2007
Last Updated: July 11, 2007
Health Authority: Germany: Ethics Commission

Keywords provided by Technische Universität München:
cardiovascular risc factors
inflammation
aerobic and exertional exercise

Additional relevant MeSH terms:
Obesity
Ventricular Dysfunction
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on April 17, 2014