Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) - Full Text View

Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

This study is currently recruiting participants.
Verified by Children's Hospital Boston, July 2007

Sponsored by:	Children's Hospital Boston
Information provided by:	Children's Hospital Boston
ClinicalTrials.gov Identifier:	NCT00499317

Purpose

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common condition with no known cure. It is estimated that every 15 seconds, a man in the USA is diagnosed with CP/CPPS. Studies have suggested that the condition may be genetic and passed down (or inherited) from one generation to the next.

In this study we are comparing different families’ samples and medical information to determine which genetic factors may play a role in CP/CPPS.

Condition

Chronic Prostatitis (CP)
Chronic Pelvic Pain Syndrome (CPPS)
Painful Bladder Syndrome (PBS)
Benign Frequency Syndrome (BFS)
Benign Daytime Frequency Syndrome (BDFS)

MedlinePlus related topics:

Interstitial Cystitis Menstruation Prostate Diseases

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study

Further study details as provided by Children's Hospital Boston:

Estimated Enrollment:	100
Study Start Date:	January 2007
Estimated Study Completion Date:	January 2009

Detailed Description:

To further describe the phenotype of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to correlate the phenotypic information with the genotypic findings utilizing linkage analysis and candidate gene studies. A North American cohort and a Bulgarian cohort will be recruited.

Eligibility

Ages Eligible for Study:	3 Years and older
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Have symptoms for at least 3 months within the preceding 6 months:
Pain in the pelvic area
Urinary frequency and/or
Urinary urgency and/or
Sexual dysfunction (erectile dysfunction)
Have CP/CPPS, IC, PBS, or BFS
Be willing to provide a saliva and urine sample
Agree to complete several brief questionnaires
Family of someone with CP/CPPS, PBS, IC or BFS
Live in the USA or Canada

Exclusion Criteria:

Major structural/anatomical urinary tract abnormalities
Underlying inborn or congenital conditions

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00499317

Contacts


Contact: Elicia Estrella, MS	617-919-4552	elicia.estrella@childrens.harvard.edu

Contact: Stephanie J. Brewster, MS	617-919-4551	stephanie.brewster@childrens.harvard.edu

Locations


United States, Massachusetts
	Children's Hospital, Boston	Recruiting
	Boston, Massachusetts, United States, 02115
	Principal Investigator: Jordan Dimitrakov, MD, PhD

Sponsors and Collaborators

Children's Hospital Boston

Investigators


Principal Investigator:	Jordan Dimitrakov, MD, PhD	Children's Hospital Boston

More Information

Publications of Results:

Dimitrakov JD. A case of familial clustering of interstitial cystitis and chronic pelvic pain syndrome. Urology. 2001 Aug;58(2):281.

Other Publications:

Dimitrakov JD, Kaplan SA, Kroenke K, Jackson JL, Freeman MR. Management of chronic prostatitis/chronic pelvic pain syndrome: an evidence-based approach. Urology. 2006 May;67(5):881-8. Review. No abstract available.

Propert KJ, Alexander RB, Nickel JC, Kusek JW, Litwin MS, Landis JR, Nyberg LM, Schaeffer AJ; Chronic Prostatitis Collaborative Research Network. Design of a multicenter randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome. Urology. 2002 Jun;59(6):870-6.

Study ID Numbers:	04-11-160M
First Received:	July 9, 2007
Last Updated:	July 9, 2007
ClinicalTrials.gov Identifier:	NCT00499317
Health Authority:	United States: Institutional Review Board

Keywords provided by Children's Hospital Boston:

Urgency

Frequency

Pelvic pain

Sexual dysfunction

Erectile dysfunction

Study placed in the following topic categories:

Pregnancy Complications

Prostatic Diseases

Urinary Bladder Diseases

Cystitis

Pain

Genital Diseases, Male

Prostatitis

Signs and Symptoms

Cystitis, Interstitial

Pelvic Pain

Pathologic Processes

Urologic Diseases

Chronic Disease

Erectile Dysfunction

Additional relevant MeSH terms:

Female Urogenital Diseases and Pregnancy Complications

Disease Attributes

Male Urogenital Diseases

Female Urogenital Diseases

Pathological Conditions, Signs and Symptoms

ClinicalTrials.gov processed this record on May 08, 2008