Anisometropia Amblyopia Improved by Perceptual Learning and Patching

This study has been completed.
Information provided by:
Tri-Service General Hospital Identifier:
First received: July 9, 2007
Last updated: NA
Last verified: July 2007
History: No changes posted

To compare the effects of perceptual learning with patching on improving visual acuity and contrast sensitivity in payient with anisometropic amblyopia.

Condition Intervention Phase
Anisometropic Amblypia
Procedure: computer program and patching
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment

Further study details as provided by Tri-Service General Hospital:

Primary Outcome Measures:
  • Corrected amblyopic logMAR visual acuity and contrast sensitivity function

Study Start Date: January 2005
Study Completion Date: January 2007
Detailed Description:

Patients with anisometropic amblyopia were randomized to patching or perceptual learning group. Corrected amblyopic logMAR visual acuity and contrast sensitivity function were measured at four-weekly intervals until visual acuity stabilized or amblyopia resolved. Improvement in visual acuity, contrast sensitivity, and the resolution of amblyopia were compared between groups.


Ages Eligible for Study:   3 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Anisometropia without strabismus
  • An interocular acuity difference of at least 0.2 logMAR in children (3–7 years of age) or in older children and adult patients without a history of patching or atropine penalization
  • All patients wore their spectacle at least one year

Exclusion Criteria:

  • A history of prior spectacle correction
  • A history of patching or optical penalization
  • The existence of an ocular disease that could contribute to decreased visual acuity
  • Learning difficulties
  • The presence of strabismus
  Contacts and Locations
Please refer to this study by its identifier: NCT00498641

Sponsors and Collaborators
Tri-Service General Hospital
Study Director: Po Chen, MD Tri-Service General Hospital
  More Information

No publications provided Identifier: NCT00498641     History of Changes
Other Study ID Numbers: 094-05-0112
Study First Received: July 9, 2007
Last Updated: July 9, 2007
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Tri-Service General Hospital:
perceptual learning
occlusion therapy processed this record on April 17, 2014