Text Size

Melatonin and Adiponectin in Hypertensive Kidney Transplant

This study has been completed.
Sponsor:
Information provided by:
Sheba Medical Center
ClinicalTrials.gov Identifier:
NCT00498576
First received: July 8, 2007
Last updated: June 29, 2009
Last verified: June 2009
History of Changes
  Purpose

Recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome. We have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients.

The aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. Secondly, to ask if there is any correlation between melatonin secretion and adiponectin levels.


Condition
Hypertension
Kidney Transplant

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Drug Information available for: Melatonin
U.S. FDA Resources

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 60
Study Start Date: September 2007
Groups/Cohorts
1
kidney transplant with hypertension
2
hypertensive patients with native kidneys
3
healthy controls

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

group1- patients from the kidney transplant unit, sheba medical center group2- patients from hypertension unit,sheba medical center

Criteria

Inclusion Criteria:

  • hypertension
  • kidney transplantation ( group 1)
  • good renal function

Exclusion Criteria:

  • diabetes mellitus
  • cancer
  • renal failure
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00498576

Locations
Israel
Sheba Medical Center
Ramat-gan, Israel
Sponsors and Collaborators
Sheba Medical Center
Investigators
Principal Investigator: Avshalom Leibowitz, MD
  More Information

No publications provided

Responsible Party: leibowitz avshalom, Sheba Medical Center
ClinicalTrials.gov Identifier: NCT00498576     History of Changes
Other Study ID Numbers: SHEBA-07-4730-AL-CTIL
Study First Received: July 8, 2007
Last Updated: June 29, 2009
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:
hypertension
kidney transplant
melatonin
adiponectin

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases
Melatonin
Central Nervous System Depressants
Physiological Effects of Drugs
 Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents

ClinicalTrials.gov processed this record on May 23, 2013