Visual Impairment, Oscillopsia and Multiple Sclerosis

This study has been terminated.
Sponsor:
Information provided by:
Hospices Civils de Lyon
ClinicalTrials.gov Identifier:
NCT00498199
First received: July 6, 2007
Last updated: September 29, 2010
Last verified: July 2007
  Purpose

This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment.

The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.


Condition Intervention
Multiple Sclerosis
Procedure: visual tests

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Visual Impairment, Oscillopsia and Multiple Sclerosis

Resource links provided by NLM:


Further study details as provided by Hospices Civils de Lyon:

Estimated Enrollment: 100
Study Start Date: April 2007
Detailed Description:

In the first part, 100 patients with multiple sclerosis are included. A vision-specific health-related quality of life scale and neuro-ophthalmological tests are administered. The duration of intervention is about 3 hours by patient and one year to finish this part.

In the second part, we include about 40 of 100 MS patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. The patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. Then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. A motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.

  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients with established multiple sclerosis

Criteria

Inclusion Criteria:

  • Age 18 to 90
  • Patients with established multiple sclerosis
  • Visual impairment recovering from MS
  • Understanding rules task
  • Patient can stay set a long time
  • Patient's agreement
  • Membership to the Social Security
  • No relapsing since three months

Exclusion Criteria:

  • Brain damage
  • Cognitive or behaviour disorder
  • Patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent
  • Not stabilized disease (other one than MS)
  • Patient under guardianship
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00498199

Locations
France
Caroline Tilikete
Lyon, France, 69677
Sponsors and Collaborators
Hospices Civils de Lyon
Investigators
Principal Investigator: Caroline Tilikete, MD Hospices Civils de Lyon
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00498199     History of Changes
Other Study ID Numbers: 2006.432
Study First Received: July 6, 2007
Last Updated: September 29, 2010
Health Authority: France: Ministry of Health

Keywords provided by Hospices Civils de Lyon:
Multiples sclerosis
oscillopsia
eye movements
motion detection
retinal slip
nystagmus

Additional relevant MeSH terms:
Multiple Sclerosis
Sclerosis
Autoimmune Diseases
Autoimmune Diseases of the Nervous System
Demyelinating Autoimmune Diseases, CNS
Demyelinating Diseases
Immune System Diseases
Nervous System Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on October 22, 2014