Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma

The recruitment status of this study is unknown because the information has not been verified recently.

Verified June 2009 by University of Erlangen-Nürnberg Medical School.
Recruitment status was Recruiting

Sponsor:

Collaborator:

German Research Foundation

Information provided by:

University of Erlangen-Nürnberg Medical School

ClinicalTrials.gov Identifier:

NCT00494923

First received: June 29, 2007

Last updated: June 15, 2009

Last verified: June 2009

History of Changes

Purpose

The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991. The primary aim is the evaluation of diagnostic and prognostic validity of morphometrical, sensory and hemodynamical diagnostic procedures. No therapeutic studies are performed.

Condition
Primary Open Angle Glaucoma Persons at Risk for Glaucoma

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Glaucoma Including Pseudoexfoliation Syndrome (SFB 539)

Resource links provided by NLM:

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

U.S. FDA Resources

Further study details as provided by University of Erlangen-Nürnberg Medical School:

Estimated Enrollment:	2500
Study Start Date:	January 1999

Detailed Description:

Purpose: Detection of onset and progression of structural and functional damage due to glaucoma. Determination of rate and amount of progressive change due to glaucoma. Characterisation of the relationship between structural and functional change over time. Evaluation of predictive factors for the development and progression of glaucoma.

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

primary care clinic

Criteria

Participants:

Patients: Primary open angle glaucoma, secondary open angle glaucoma due to PEX or MDS, glaucoma suspects including ocular hypertension
Healthy volunteers (for cross sectional analysis only)

Inclusion Criteria:

Open anterior chamber angle
Best corrected visual acuity 0.7 or better
Age between 18 and 65 years

Exclusion Criteria:

Any eye disease other than glaucoma
Systemic diseases with potentially ocular involvement (e.g., diabetes mellitus)
Myopic or hyperopic refractive error exceeding 8.0 diopters

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00494923

Contacts

Contact: Anselm G Juenemann, Prof.

**49-9131-8533001

anselm.juenemann@uk-erlangen.de

Locations

Germany
University Eye Hospital	Recruiting
Erlangen, Germany, 91054
Contact: Robert Laemmer, MD **49-9131-8533001 robert.laemmer@uk-erlangen.de
Principal Investigator: Christian Y Mardin, Prof.
Principal Investigator: Folkert K Horn, PhD
Principal Investigator: Georg Michelson, Prof.

Sponsors and Collaborators

University of Erlangen-Nürnberg

German Research Foundation

Investigators

Study Chair:

Anselm G Juenemann, Prof.

University Erlangen-Nuremberg

More Information

No publications provided by University of Erlangen-Nürnberg Medical School

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Horn FK, Kaltwasser C, Jünemann AG, Kremers J, Tornow RP. Objective perimetry using a four-channel multifocal VEP system: correlation with conventional perimetry and thickness of the retinal nerve fibre layer. Br J Ophthalmol. 2012 Apr;96(4):554-9. Epub 2011 Nov 24.

Barboni MT, Pangeni G, Ventura DF, Horn F, Kremers J. Heterochromatic flicker electroretinograms reflecting luminance and cone opponent activity in glaucoma patients. Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6757-65. Print 2011 Aug.

Horn FK, Mardin CY, Laemmer R, Baleanu D, Juenemann AM, Kruse FE, Tornow RP. Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT. Invest Ophthalmol Vis Sci. 2009 May;50(5):1971-7. Epub 2009 Jan 17.

Responsible Party:	University Eye Hospital Erlangen, University of Erlangen-Nürnberg
ClinicalTrials.gov Identifier:	NCT00494923 History of Changes
Other Study ID Numbers:	DFG-SFB539-R
Study First Received:	June 29, 2007
Last Updated:	June 15, 2009
Health Authority:	Germany: Ethics Commission

Additional relevant MeSH terms:

Glaucoma
Glaucoma, Open-Angle
Exfoliation Syndrome
Ocular Hypertension

Eye Diseases
Iris Diseases
Uveal Diseases

ClinicalTrials.gov processed this record on May 23, 2013

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