Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2013 by Stanford University
Information provided by (Responsible Party):
Stanford University Identifier:
First received: June 20, 2007
Last updated: October 24, 2013
Last verified: October 2013

This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.

Condition Intervention
Behavioral: Cognitive rehabilitation
Device: MRI

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Performance on neuropsychological testing and brain activation patterns measured by functional MRI [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 15
Study Start Date: August 2007
Estimated Study Completion Date: August 2014
Estimated Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive rehabilitation Behavioral: Cognitive rehabilitation
Standard of Care
Other Name: Cognitive rehabilitation therapy
Device: MRI
Standard of Care
Other Name: Magnetic Resonance Imaging

Detailed Description:

The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.


Ages Eligible for Study:   9 Years to 16 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 5 children with any type of cancer in the initial stages of chemotherapy and/or cranial radiation.
  • 10 children with any type of cancer who have completed chemotherapy and cranial radiation.

Exclusion Criteria:

  • Children with pre-cancer/pre-chemotherapy history of brain injury, neurological, psychiatric, neurodevelopmental and/or learning disorders including attention deficit hyperactivity disorder will be excluded.
  • Participants will be excluded for MRI contraindications such as orthodontia and biomedical implants.
  • Non-English speaking participants will be excluded due to the unavailability at this time of translated cognitive testing and MRI assessments.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00490334

United States, California
Stanford University School of Medicine Recruiting
Stanford, California, United States, 94305
Contact: Shelli Kesler, PhD    650-723-0058   
Contact: Cancer Clinical Trials Office    (650) 498-7061      
Principal Investigator: Shelli Kesler         
Sub-Investigator: Allan L Reiss         
Sponsors and Collaborators
Stanford University
Principal Investigator: Shelli Kesler Stanford University
  More Information

No publications provided

Responsible Party: Stanford University Identifier: NCT00490334     History of Changes
Other Study ID Numbers: PEDSVAR0003, 97817, PEDSVAR0003
Study First Received: June 20, 2007
Last Updated: October 24, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Stanford University:
Squamous Cel
Acute Lymphocytic Leukemia

Additional relevant MeSH terms:
Cognition Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders processed this record on October 23, 2014