Periodontal and Periapical Inflammation and Pregnancy

The recruitment status of this study is unknown because the information has not been verified recently.

Verified January 2008 by University of Mississippi Medical Center. Recruitment status was Active, not recruiting

First Received on June 20, 2007. Last Updated on January 7, 2008 History of Changes

Sponsor:	University of Mississippi Medical Center
Information provided by:	University of Mississippi Medical Center
ClinicalTrials.gov Identifier:	NCT00490165

Purpose

This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.

Condition
Periodontal Disease Periapical Disease Pregnancy Diabetes Cardiovascular Disease Dental Caries

Study Type:	Observational
Study Design:	Time Perspective: Retrospective
Official Title:	Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes

Resource links provided by NLM:

Genetics Home Reference related topics: 6q24-related transient neonatal diabetes mellitus

MedlinePlus related topics: Tooth Decay

U.S. FDA Resources

Further study details as provided by University of Mississippi Medical Center:

Estimated Enrollment:	500
Study Start Date:	March 2007

Show Detailed Description

Eligibility

Ages Eligible for Study:	10 Years and older
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.

Criteria

Inclusion Criteria:

Female
Child bearing age or above

Exclusion Criteria:

Male
Very young children (before child-bearing age)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00490165

Locations

United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39202

Sponsors and Collaborators

University of Mississippi Medical Center

Investigators

Principal Investigator:	Jennifer L Bain, BS	University of Mississippi Medical Center
Study Director:	Roger Johnson, PhD; DMD	University of Mississippi Medical Center

More Information

No publications provided

Responsible Party:	Roger Johnson/Study Sponsor/Professor, University of Mississippi Medical Center
ClinicalTrials.gov Identifier:	NCT00490165 History of Changes
Other Study ID Numbers:	2006-0198
Study First Received:	June 20, 2007
Last Updated:	January 7, 2008
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:

Cardiovascular Diseases
Dental Caries
Inflammation
Periapical Diseases
Periodontal Diseases
Tooth Demineralization

Tooth Diseases
Stomatognathic Diseases
Pathologic Processes
Jaw Diseases
Mouth Diseases

ClinicalTrials.gov processed this record on February 09, 2012