Assessment of Pulmonary Involvement inUlcerative Colitis by Induced Sputum

This study has been completed.
Sponsor:
Information provided by:
Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier:
NCT00490048
First received: June 21, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted
  Purpose

Ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A Fireman E: Assessment of pulmonary involvement in Crohn’s disease by induced sputum. Am J Gastroenterol 2000;95(30):730-734. )


Condition Intervention
Ulcerative Colitis
Procedure: Induced sputum (inhalation of 3.5% saline)

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening

Resource links provided by NLM:


Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:
  • lung involvment in Ulcerative colitis patients

Estimated Enrollment: 20
Study Start Date: June 2007
Study Completion Date: June 2007
Detailed Description:

Twenty Ulcerative colitis patients and 20 control subjects (all nonsmokers) without respiratory symptoms will be tested. The induce sputum by 20' inhalation of 3.5% saline using ultrasonic nebulizer. Samples will studied by differential counts of 200 cells on cytopreps stained by Giemsa. T-lymphocyte subset analyses were done by FACS using three monoclonal antibodies: CD3 = total T cells, CD4 = T helper cells, and CD8 = T suppressor-cytotoxic cells. CD4/CD8 >2.5 was considered abnormal.

  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All the ulceratvive colitis patients without lung involvmentage 18-75 years of age

Exclusion Criteria:

  • Pregnant women
  • Non cooperative patients
  • Smoker
  • Lung disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00490048

Sponsors and Collaborators
Hillel Yaffe Medical Center
Investigators
Principal Investigator: Zvi Fireman, MD Hillel- Yaffe Med. Ctr
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00490048     History of Changes
Other Study ID Numbers: ISUC.CTIL
Study First Received: June 21, 2007
Last Updated: June 21, 2007
Health Authority: Israel: Ministry of Health

Keywords provided by Hillel Yaffe Medical Center:
Ulcerative colits
lung
Induced sputum
Our aim to evaluate lung involvement in Ulcerative colitis patients by induced sputum

Additional relevant MeSH terms:
Colitis
Colitis, Ulcerative
Ulcer
Colonic Diseases
Digestive System Diseases
Gastroenteritis
Gastrointestinal Diseases
Inflammatory Bowel Diseases
Intestinal Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on October 21, 2014