Trial record 1 of 23 for:    "Long QT syndrome"
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The Long QT Syndrome in Pregnancy

This study has been completed.
Sponsor:
Information provided by:
University of British Columbia
ClinicalTrials.gov Identifier:
NCT00488254
First received: June 18, 2007
Last updated: April 12, 2011
Last verified: April 2011
  Purpose

Long QT Syndrome (LQTS) is a disease of young adults and can affect women of child bearing age. Suffers of LQTS are at risk of ventricular dysrhythmias including torsades de pointes and ventricular fibrillation.

Pregnancy increases the chance that any mother may have an abnormal heart rhythm or arrhythmia. This chance is higher with the LQTS. There are only a few reported cases of women with the LQTS having a baby in the medical literature. This can make it difficult for the doctor caring for a pregnant woman with the long QT syndrome - especially should they need an anesthetic.

We would like to study as many women who have had a baby who have the long QT syndrome to give us a better idea of whether there are any arrhythmias occurring at the time of delivery.


Condition
Long QT Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Long QT Syndrome in Pregnancy

Resource links provided by NLM:


Further study details as provided by University of British Columbia:

Estimated Enrollment: 12
Study Start Date: June 2007
Study Completion Date: April 2008
Detailed Description:

This will be a retrospective analysis of all LQTS women managed at St. Paul's or BC Women's who have been pregnant in the last 5 years. These two hospitals both have a provincial role in the care of pregnant women, BC Women's as the designated provincial tertiary maternity care referral centre, and St. Paul's through its provincial PATCH clinic. Using the data from these two centres should capture the majority of LQTS cases in parturients in the province. We will search for these women from the Department of Anesthesia BC Women's consult database, the St. Paul's Cardiac Obstetrical Care database, and BC Women's Health Records using International Classification of Diseases - 10 coding for long QT. Then, after obtaining patient consent, review the charts collecting data using the data entry form. The cases will then be compared and any conclusions into the different anesthetic managements made.

  Eligibility

Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Women managed at St. Paul's or BC Women's, Vancouver, who have been pregnant in the last 5 years

Criteria

Inclusion Criteria:

  • Pregnant women with diagnoses of Long QT Syndrome, Romano Ward and Jervell - Lange Nielson Syndrome who delivered at BC Women's Hospital or St Paul's Hospital.

Exclusion Criteria:

  • Non consent to participation in the study
  • Age less than 19
  • Non English speaker
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00488254

Locations
Canada, British Columbia
BC Women's Hospital
Vancouver, British Columbia, Canada
Sponsors and Collaborators
University of British Columbia
Investigators
Principal Investigator: Roanne Preston, MD University of British Columbia
Study Director: Elizabeth Drake, MD University of British Columbia
Study Director: Joanne Douglas, MD University of British Columbia
Study Director: Marla Kiess, MD University of British Columbia
Study Director: Stanley Tung, MD University of British Columbia
  More Information

No publications provided

Responsible Party: Dr. Roanne Preston, University of British Columbia
ClinicalTrials.gov Identifier: NCT00488254     History of Changes
Other Study ID Numbers: H06-03385
Study First Received: June 18, 2007
Last Updated: April 12, 2011
Health Authority: Canada: Health Canada

Keywords provided by University of British Columbia:
Long QT Syndrome
Romano Ward
Jervell-Lange Nielson Syndrome

Additional relevant MeSH terms:
Long QT Syndrome
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Heart Defects, Congenital
Cardiovascular Abnormalities
Congenital Abnormalities
Pathologic Processes

ClinicalTrials.gov processed this record on July 26, 2014