Alterations of Immunologic Mediators During Severe Sepsis (LAVISS_01)
Severe sepsis induces significant changes in expression of insulin- and toll-like receptors, cytokines, markers of apoptosis, and activation of t- and b-lymphocytes.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Alterations of Immunologic Mediators During Severe Sepsis|
Whole Blood Samples, Plasma Samples
|Study Start Date:||June 2006|
|Estimated Study Completion Date:||December 2012|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
In patients at early stage of severe sepsis, we investigate the expression of pro- and anti-inflammatory cytokines, chemokines, adhesion-molecules, toll-like receptors, insulin-receptors, markers of apoptosis und of t- and b-cell-activation on a mRNA level.
|Klinikum St. Georg gGmbH, Interdisciplinary Intensive Care Unit|
|Leipzig, Sachsen, Germany, 04129|
|Principal Investigator:||Armin R Sablotzki, MD||Klinikum St. Georg gGmbH|