The DIEP-Flap as a Model of Ischemia-Reperfusion

This study has been completed.
Information provided by:
Maastricht University Medical Center Identifier:
First received: June 4, 2007
Last updated: January 6, 2009
Last verified: January 2009

It is our goal to study the mechanism of ischemia-reperfusion injury. Our DIEP-operation is actually a clinical model of ischemia-reperfusion. Ischemia-reperfusion injury has never been directly studied in a human, clinical model of autologous transplant.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The DIEP-Flap as a Model of Ischemia-Reperfusion

Further study details as provided by Maastricht University Medical Center:

Biospecimen Retention:   Samples With DNA

Frozen tissue.

Enrollment: 45
Study Start Date: April 2007
Study Completion Date: November 2008

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Clinical patients hospitalized for surgery.


Inclusion Criteria:

  • patient is undergoing a DIEP-breast reconstruction, unilateral as well as bilateral
  • is aged 18 years or older

Exclusion Criteria:

  • diabetes mellitus
  • diseases of the kidneys
  • diseases of the liver
  • patients who are taking immunosuppressants
  Contacts and Locations
Please refer to this study by its identifier: NCT00482469

Department of Plastic and Reconstructive surgery, Maastricht University Hospital
Maastricht, Netherlands, P.O. Box 5800-6202 AZ
Sponsors and Collaborators
Maastricht University Medical Center
Study Chair: René R Van der Hulst, MD, PhD Maastricht University Hospital
Principal Investigator: Marieke GW Van den Heuvel, MD Maastricht University Hospital
  More Information

No publications provided by Maastricht University Medical Center

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr. R. van der Hulst, M.D., University Hospital Maastricht Identifier: NCT00482469     History of Changes
Other Study ID Numbers: MEC 07-2-004
Study First Received: June 4, 2007
Last Updated: January 6, 2009
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Maastricht University Medical Center:

Additional relevant MeSH terms:
Pathologic Processes processed this record on April 17, 2014