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Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

This study has been completed.
Sponsor:
Information provided by:
Universita di Verona
ClinicalTrials.gov Identifier:
NCT00477789
First received: May 23, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
  Purpose

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.


Condition Intervention Phase
Chronic Heart Failure
 Drug: allopurinol
 Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Resource links provided by NLM:

MedlinePlus related topics: Heart Failure
U.S. FDA Resources

Further study details as provided by Universita di Verona:

Primary Outcome Measures:
  • diastolic function uric acid levels BNP [ Time Frame: three months ]

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • chronic heart failure;
  • left ventricular systolic dysfunction (ejection fraction <45%)
  • stable clinical conditions in the previous three months
  • optimal medical therapy for CHF
  • normal sinus rhythm
  • written informed consent
  • age >18 years

Exclusion Criteria:

  • renal failure (s-creatinine >2.5 mg/dl)
  • already on allopurinol
  • malignancies
  • chronic inflammatory diseases
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00477789

Locations
Italy
Division of Cardiology, University Hospital of Verona
Verona, Italy, 37129
Sponsors and Collaborators
Universita di Verona
Investigators
Principal Investigator: Mariantonietta Cicoira, MD, PhD Division of Cardiology, University of Verona, Italy
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00477789     History of Changes
Other Study ID Numbers: 802
Study First Received: May 23, 2007
Last Updated: May 23, 2007
Health Authority: Italy: Ethics Committee

Keywords provided by Universita di Verona:
chronic heart failure
diastolic dysfunction
uric acid

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Allopurinol
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Gout Suppressants
 Antirheumatic Agents
Therapeutic Uses
Free Radical Scavengers
Antioxidants
Antimetabolites
Protective Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on June 17, 2013